17688-68-5

Basic information

• Product Name: 4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE
• Synonyms: thiomorpholine,4-phenyl-,1,1-dioxide;CHEMPACIFIC 36183;4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE;4-phenyl-1,4-thiazinane 1,1-dioxide
• CAS NO: 17688-68-5
• Molecular Formula: C₁₀H₁₃NO₂S
• Molecular Weight: 211.28
• EINECS: 241-675-3
• Mol File: 17688-68-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 427.8°Cat760mmHg
• Flash Point: 212.5°C
• Appearance: /
• Density: 1.255g/cm³
• CAS DataBase Reference: 4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE(17688-68-5)
• EPA Substance Registry System: 4-PHENYLTHIOMORPHOLINE 1,1-DIOXIDE(17688-68-5)

Safety Data

• RTECS: XM3050025
• Hazardous Substances Data: 17688-68-5(Hazardous Substances Data)

Usage

General Description

4-Phenylthiomorpholine 1,1-dioxide, also known as Carvedilol, is a medication used to treat high blood pressure and heart failure. It belongs to a class of drugs called beta-blockers and works by relaxing blood vessels and slowing the heart rate to improve blood flow and decrease blood pressure. It is also used to prevent further heart damage after a heart attack. Carvedilol is usually taken by mouth and comes in tablet form. Common side effects may include dizziness, fatigue, and low blood pressure. It is important to follow the prescribed dosage and consult a healthcare professional before starting or stopping this medication.

InChI:InChI=1/3C2H4O2.Ce.H2O/c3*1-2(3)4;;/h3*1H3,(H,3,4);;1H2/q;;;+3;/p-3

Upstream product

• 77-79-2 3-Sulfolene 
• 62-53-3 aniline 
• 39093-93-1 thiomorpholine 1,1-dioxide 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 77-77-0 Divinyl sulfone 
• 98-95-3 nitrobenzene 
• 471-03-4 bis(2-chloroethyl)sulfone 
• 358-79-2 bis-(2-fluoro-ethyl)-sulfone 

Downstream Products

• 39093-93-1 thiomorpholine 1,1-dioxide 
• 102101-85-9 [4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-phenyl]-(4-trifluoromethyl-phenyl)-diazene 
• 102101-84-8 (4-Chloro-phenyl)-[4-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-phenyl]-diazene 
• 78866-05-4 [4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-phenyl]-(4-methoxy-phenyl)-diazene 
• 102101-87-1 [4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-phenyl]-(4-nitro-phenyl)-diazene 
• 102101-86-0 4-[4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-phenylazo]-benzonitrile 
• 55330-78-4 4-phenyl-1-thia-4-azacyclohexane 
• 27913-96-8 4-(1,1-dioxo-4-thiomorpholin-4-yl)benzaldehyde 

Relevant articles and documents

Aminomercuration-Demercuration of Divinyl Sulfone: Synthesis of 4-Aryltetrahydro-1,4-thiazine 1,1-Dioxides

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Spectroscopic Studies of the Chan-Lam Amination: A Mechanism-Inspired Solution to Boronic Ester Reactivity

We report an investigation of the Chan-Lam amination reaction. A combination of spectroscopy, computational modeling, and crystallography has identified the structures of key intermediates and allowed a complete mechanistic description to be presented, including off-cycle inhibitory processes, the source of amine and organoboron reactivity issues, and the origin of competing oxidation/protodeboronation side reactions. Identification of key mechanistic events has allowed the development of a simple solution to these issues: manipulating Cu(I) → Cu(II) oxidation and exploiting three synergistic roles of boric acid has allowed the development of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine and organoboron limitations of this valuable transformation.

Boric acid/glycerol as an efficient catalyst for synthesis of thiomorpholine 1,1-dioxide by double michael addition reaction in water

Thiomorpholine 1,1-dioxides were prepared with double Michael addition reaction of aromatic amines to divinyl sulfone catalyzed by boric acid/glycerol in water. This catalyst system was also used for the Michael addition reaction of aromatic amines to electron-deficient alkenes. The reaction is simple and green and gives good to excellent yields.