17692-38-5

Basic information

• Product Name: Fluprofen
• Synonyms: 3'-Fluoro-α-methylbiphenyl-4-acetic acid;BTS-17345;RD-17345
• CAS NO: 17692-38-5
• Molecular Formula: C15H13FO2
• Molecular Weight: 244.264
• Mol File: 17692-38-5.mol

Chemical Properties

• Boiling Point: 389.5 °C at 760 mmHg
• Flash Point: 189.3 °C
• Appearance: /
• Density: 1.199 g/cm³
• Vapor Pressure: 9.18E-07mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: Fluprofen(CAS DataBase Reference)
• NIST Chemistry Reference: Fluprofen(17692-38-5)
• EPA Substance Registry System: Fluprofen(17692-38-5)

Safety Data

• Hazardous Substances Data: 17692-38-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H13FO2/c1-10(15(17)18)11-5-7-12(8-6-11)13-3-2-4-14(16)9-13/h2-10H,1H3,(H,17,18)

Relevant articles and documents

High molecular weight prodrug derivatives of antiinflammatory drugs

Compounds of the formula 1, PS - O - A - (CH2)n- B - D (1), wherein PS-O represents an alkoxide residue of any of the free hydroxy groups of a polysaccharide (PS-OH) compound with molecular weight (Mw) of from 40,000 to 5,000,000 selected from dextran, carboxymethyl dextran, diethylaminoethyl dextran, starch, hydroxyet-hyl starch, alginates, glycogen, pullullan, agarose, cellulose, chitosan, chitin and carrageenan,A is a carbonyl group or absent,n is zero or a positive integer from 1 to 14,B is oxygen, a carbonyl group, NR wherein R is hydrogen or lower alkyl, or B is absent, and, D is (i) a group of the formula:, R1 - CO - (11), wherein R1-CO- represents the acyl residue of a carboxylic acid drug (R1-COOH) used in the treatment of inflammatory disorders; or (ii) a group of the formula:, R2 - O - (12), wherein R2-O- refers to the C-21 alkoxide residue of a known antiinflammatory steroid (R2-OH) or an alkoxide residue of any other drug or medicament containing a hydroxy functional group used in the treatment of inflammatory disorders; with the proviso that when A is absent, n is 0, and B is absent, then R1-CO- is different from the acyl residue of acetylsalicylic acid;, and non-toxic pharmaceutically acceptable acid addition salts thereof;, and non-toxic pharmaceutically acceptable cation salts thereof. Such compounds are biolabile prodrugs providing controlled release and prolonged duration of action of the parent active antiinflamma-tory agents locally at the administration site after intra-articular, intra-muscular, subcutaneous or extra-dural application while at the same time being highly stable in aqueous solution in the pH range 3--5. After oral administration of such prodrugs the parent drug is liberated selectively in the terminal ileum and the colon over an extended period of time.