17742-69-7

Basic information

• Product Name: 2,6-DICHLORO-4-NITROANISOLE
• Synonyms: 2,6-DICHLORO-4-NITROANISOLE;1,3-DICHLORO-2-METHOXY-5-NITROBENZENE;4-Nitro-2,6-dichloroanisole;3,5-Dichloro-4-methoxynitrobenzene;1,3-Dichloro-2-Methoxy-5-Nitro;2,6-DICHLORO-4-NITROANISOLE 99%;1,3-DICHLORO-2-METHOXY-5-NITROBENZENE,99%;1,3-Dichloro-5-Methoxy-2-nitrobenzene
• CAS NO: 17742-69-7
• Molecular Formula: C₇H₅Cl₂NO₃
• Molecular Weight: 222.03
• EINECS: 403-350-6
• Product Categories: Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Nitro Compounds
• Mol File: 17742-69-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 97-100 °C
• Boiling Point: 305.571 °C at 760 mmHg
• Flash Point: 160 °C
• Appearance: slightly beige crystals
• Density: 1.5223 (rough estimate)
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.6140 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Sparingly), Chloroform (Slightly)
• Water Solubility: 26 mg l-1 (e)
• CAS DataBase Reference: 2,6-DICHLORO-4-NITROANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-4-NITROANISOLE(17742-69-7)
• EPA Substance Registry System: 2,6-DICHLORO-4-NITROANISOLE(17742-69-7)

Safety Data

• Hazard Codes: N-T,T,N
• Statements: 51/53-25
• Safety Statements: 61-45-36/37
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 17742-69-7(Hazardous Substances Data)

Usage

Chemical Properties

slightly beige crystals

Uses

2,6-Dichloro-4-nitroanisole can be used for thyroid hormone receptor agonists.

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 1656, 1963 DOI: 10.1021/jo01041a056

InChI:InChI=1/C7H5Cl2NO3/c1-13-7-5(8)2-4(10(11)12)3-6(7)9/h2-3H,1H3

Upstream product

• 13633-34-6 1,3-dichloro-2,5-dinitro-benzene 
• 124-41-4 sodium methylate 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 99-30-9 4-nitro-2,6-dichloroaniline 
• 3107-19-5 3,5-dichloro-4-fluoro-nitrobenzene 
• 618-80-4 2,6-dichloro-4-nitrophenol 
• 20098-48-0 3,4,5-trichloronitrobenzen 

Downstream Products

• 95646-32-5 (2,6-Dichloro-4-nitro-phenyl)-isopropyl-amine 
• 204634-62-8 1-(3,5-dichloro-4-methoxyphenyl)piperazine 
• 1260754-30-0 C₉H₅Cl₃N₂OS₂ 
• 32407-11-7 3,5-dichloro-4-methoxyaniline 
• 100623-27-6 2-(3,5-dichloro-4-methoxyphenylamino)benzoic acid 
• 128207-16-9 N-(2,3,5-trichloro-4-methoxyphenyl)acetamide 
• 3336-38-7 3,5-dichloro-4-methyloxybenzonitrile 
• 90650-14-9 acetic acid-(3,5-dichloro-4-methoxy-anilide) 
• 421766-14-5 2,3,5-trichloroanisidine 
• 70439-96-2 2,3,5,6-tetrachloroanisidine 
• 88135-30-2 2-(2,6-dichloro-4-nitrophenyl)acetonitrile 

Relevant articles and documents

THYROID HORMONE RECEPTOR AGONISTS

Provided herein are novel thyroid hormone receptor (TR) agonists, e. g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.

COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

The invention relates to a compound of Formula (I) or (IA) compositions comprising compounds of Formula (I) or (IA), and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula (I) or (IA) to a patient in need thereof: