Welcome to LookChem.com Sign In|Join Free

CAS

  • or

179113-90-7

Post Buying Request

179113-90-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

179113-90-7 Usage

Description

3-Trifluoromethoxyphenylboronic acid is an organic compound that serves as a versatile reagent and intermediate in organic synthesis, particularly in the field of medicinal chemistry. It is characterized by its almost white to slightly beige powder and chunk form.

Uses

Used in Suzuki Reaction:
3-Trifluoromethoxyphenylboronic acid is used as a reagent in the Suzuki reaction, a widely employed cross-coupling reaction in organic chemistry for the formation of carbon-carbon bonds.
Used in Pharmaceutical Industry:
3-Trifluoromethoxyphenylboronic acid is used as a precursor in the synthesis of various biologically active compounds, including:
1. Multisubstituted purines as P2X7 antagonists for the treatment of pain.
2. Heteroaryl substituted tetrahydropyrroloijquinolinone derivatives as aldosterone synthase inhibitors.
3. Fluorohydroquinolineethanol as a CETP inhibitor.
4. Biaryl amides with muscarinic acetylcholine receptor subtype M1 agonist activity.
5. C2-aryl pyrrolobenzodiazepine antitumor agents.
6. Piperazine-bisamide for obesity treatments.
Additionally, 3-(Trifluoromethyloxy)phenylboronic acid is used as a reagent in the preparation of pyrrolo[1,2-a]pyrazinones, which act as inhibitors of PIM kinases, playing a significant role in the development of targeted cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 179113-90-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,9,1,1 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 179113-90:
(8*1)+(7*7)+(6*9)+(5*1)+(4*1)+(3*3)+(2*9)+(1*0)=147
147 % 10 = 7
So 179113-90-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BF3O3/c9-7(10,11)14-6-3-1-2-5(4-6)8(12)13/h1-4,12-13H

179113-90-7 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (T2362)  3-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)  

  • 179113-90-7

  • 5g

  • 700.00CNY

  • Detail

179113-90-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-(trifluoromethoxy)phenyl]boronic acid

1.2 Other means of identification

Product number -
Other names 3-(Trifluoromethoxy)benzeneboronic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:179113-90-7 SDS

179113-90-7Relevant articles and documents

Scalable, Metal- and Additive-Free, Photoinduced Borylation of Haloarenes and Quaternary Arylammonium Salts

Mfuh, Adelphe M.,Doyle, John D.,Chhetri, Bhuwan,Arman, Hadi D.,Larionov, Oleg V.

supporting information, p. 2985 - 2988 (2016/03/19)

We report herein a simple, metal- and additive-free, photoinduced borylation of haloarenes, including electron-rich fluoroarenes, as well as arylammonium salts directly to boronic acids. This borylation method has a broad scope and functional group tolerance. We show that it can be further extended to boronic esters and carried out on gram scale as well as under flow conditions.

2-, 3-, and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds

Castagnetti, Eva,Schlosser, Manfred

, p. 691 - 695 (2007/10/03)

Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivatives in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The 3- and 4-isomers can readily be generated from the corresponding 3- and 4-bromo precursors by halogen-metal interconversion with butyllithium or tertbutyllithium. Upon trapping of the 2-, 3- and 4-(trifluoromethoxy)phenyllithiums with 11 different electrophiles the expected products were formed in generally high yields. Only the attempted nucleophilic addition of 2-(trifluoromethoxy)phenyllithium to oxirane did not succeed. This failure is tentatively attributed to a lowering of the nucleophilicity by fluorine-lithium interactions. Conformationally restricted analogs - i.e., 2,2-difluoro-1,3-benzodioxol-4-phenyllithium and its 5-fluoro- and 5-bromo-substituted congeners - did indeed react smoothly with oxirane, affording the adducts in ordinary yields.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 179113-90-7