17918-14-8

Basic information

• Product Name: 2,5-DIMETHOXYBENZOYL CHLORIDE
• Synonyms: 2,5-DIMETHOXYBENZOYL CHLORIDE;2,5-DIMETHOXYBENZENE-1-CARBONYL CHLORIDE;BUTTPARK 48\04-28;2,5-Dimethoxybenzoic acid chloride
• CAS NO: 17918-14-8
• Molecular Formula: C₉H₉ClO₃
• Molecular Weight: 200.62
• EINECS: 241-863-5
• Mol File: 17918-14-8.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 179°C/10mm
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.224 g/cm³
• Vapor Pressure: 0.000757mmHg at 25°C
• Refractive Index: 1.52
• CAS DataBase Reference: 2,5-DIMETHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYBENZOYL CHLORIDE(17918-14-8)
• EPA Substance Registry System: 2,5-DIMETHOXYBENZOYL CHLORIDE(17918-14-8)

Safety Data

• Hazardous Substances Data: 17918-14-8(Hazardous Substances Data)

Usage

Preparation

AlCl3 (4.0 g, 30 mmol) was suspended in dichloromethane (30 mL). To this mixture, a solution of 1,4- dimethoxybenzene (1.38 g, 10 mmol) and triphosgene (5.94 g, 20 mmol) in dichloromethane (30 mL) was added dropwise over a period of 30 min. The resulting mixture was stirred under reflux for 7 days. It was then poured into crushed ice/ water (50 mL) and stirred with pyridine (0.5 mL) at 0 ℃ for 10 min. The layers were separated and the aqueous phase was extracted with dichloromethane (2 ×20 mL). The combined organic layers were washed with ice-cold 0.5 m HCl (30 mL) and with ice-cold water (2×10 mL), and dried over sodium sulfate. The solvent was evaporated in vacuo and the residue was purified by chromatography on silica gel, eluting with hexane/ethyl acetate (4:1→3:1→2:1→1:1), to afford 1.23 g (60%) of 2,5-dimethoxybenzoyl chloride.

InChI:InChI=1/C9H9ClO3/c1-12-6-3-4-8(13-2)7(5-6)9(10)11/h3-5H,1-2H3

Upstream product

• 2785-98-0 2,5-dimethoxybenzoic acid 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 

Downstream Products

• 42020-21-3 2,5-dimethoxybenzamide 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 100940-14-5 1,4-bis(2,5-dimethoxybenzoyl)piperazine 
• 22961-80-4 2-Hydroxy-2',3,4,5,5',6-hexamethoxybenzophenon 
• 22804-55-3 2,2',3,4,5,5',6-Heptamethoxybenzophenon 
• 443643-14-9 1-(2',5'-dimethoxyphenyl)-4-(pyridin-2-yl)acylamidrazone 
• 52405-61-5 N-(2,5-dimethoxyphenyl)-2,5-dimethoxybenzamide 
• 72003-93-1 N,N-diethyl-2,5-dimethoxybenzamide 
• 208647-41-0 (1'R,2'S,5'R)-(-)-menthyl 2,5-dimethoxybenzoate 
• 23251-65-2 2-Hydroxy-2',3,4,5',6-pentamethoxybenzophenon 
• 129168-53-2 2-Hydroxy-2',3,4,5,5'-pentamethoxybenzophenon 
• 42833-59-0 2'-Hydroxy-2,4',5,6'-tetramethoxybenzophenon 
• 42832-64-4 2-hydroxy-5-methoxyphenyl 2,4,6-trimethoxyphenylmethanone 
• 100940-08-7 4-(2,5-Dimethoxy-benzoyl)-piperazine-1-carbaldehyde 

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