179333-98-3Relevant articles and documents
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine. Synthesis, receptor affinity, and antinociceptive activity
Sauerberg, Per,Olesen, Preben H.,Sheardown, Malcolm J.,Rimvall, Karin,Th?gersen, A Henning,Shannon, Harlan E.,Sawyer, Barry D.,Ward, John S.,Bymaster, Frank P.,Delapp, Neil,Calligaro, David O.,Swedberg, Michael D. B.
, p. 109 - 116 (2007/10/03)
Conformationally constrained analogues of the potent muscarinic agonist 3-(4-(methylthio)l,2,5-thiadiazol-3-yl)-l,2,5,6-tetrahydro-l-methylpyridine (methylthio-TZTP, 17) were designed and synthesized with the aim of (a) improving the antinociceptive selec