179420-56-5Relevant articles and documents
5-Lipoxygenase inhibitors: Convenient synthesis of 4-[3-(4- heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues
Mano, Takashi,Stevens, Rodney W.,Okumura, Yoshiyuki,Kawai, Makoto,Okumura, Takako,Sakakibara, Minoru
, p. 2611 - 2615 (2007/10/03)
A convenient synthetic route to 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4, 5,6-tetrahydro-2H-pyran-4-carboxamide analogues as 5-LO inhibitors is described. This methodology enabled rapid development of structure-activity relationships (SARs) leading to i
5-lipoxygenase inhibitors
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, (2008/06/13)
Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: STR1 and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, py