179692-09-2

Basic information

• Product Name: 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI)
• Synonyms: 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI);ethyl 4-formyl-1H-pyrazole-3-carboxylate;Albb-007090;ethyl 4-formyl-1H-pyrazole-3-carboxylate(SALTDATA: FREE);1H-Pyrazole-3-carboxylicacid, 4-forMyl-, ethyl ester;2H-Pyrazole-3-carboxylic acid, 4-formyl-, ethyl ester;4-Formyl-1H-pyrazole-3-carboxylic acid ethyl ester;4-formyl-2H-pyrazole-3-carboxylic acid ethyl ester
• CAS NO: 179692-09-2
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD;Heterocycles
• Mol File: 179692-09-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 382.9°C at 760 mmHg
• Flash Point: 185.4°C
• Appearance: /
• Density: 1.323g/cm³
• Vapor Pressure: 4.55E-06mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI)(179692-09-2)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI)(179692-09-2)

Safety Data

• Hazardous Substances Data: 179692-09-2(Hazardous Substances Data)

Usage

General Description

1H-Pyrazole-3-carboxylic acid, 4-formyl-, ethyl ester (9CI) is a chemical compound with the molecular formula C7H8N2O3. It is a derivative of pyrazole and is commonly used in the synthesis of pharmaceuticals and agrochemicals. 1H-Pyrazole-3-carboxylicacid,4-formyl-,ethylester(9CI) is a pale yellow liquid with a fruity odor. It is used as a building block in organic synthesis and as a reagent in chemical reactions. Its properties and structure make it useful for a variety of applications in the fields of chemistry and biochemistry. However, it is important to handle this compound with care, as it can be toxic if ingested or inhaled and can cause irritation to the skin and eyes.

InChI:InChI=1/C7H8N2O3/c1-2-12-7(11)6-5(4-10)3-8-9-6/h3-4H,2H2,1H3,(H,8,9)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 14923-66-1 ethyl 2-(carbamoylhydrazono)propanoate 
• 14923-66-1 ethyl 2-(2-carbamoylhydrazono)propanoate 
• 617-35-6 2-oxo-propionic acid ethyl ester 

Downstream Products

• 1224171-59-8 2-(5-chloropyridin-2-yl)-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one 

Relevant articles and documents

A new synthethic approach to indazole synthesis

Stobbe condensation of 3-alkyl- or aryl-4-formylpyrazoles 3a-f with diethyl succinate in the presence of potassium f-butoxide, followed by intramolecular ring closure (Ac2O-NaOAc), afforded the corresponding indazole derivatives 5a-f in 65-85% overall yield. These compounds are good starting materials for transformation to biologically active molecules, such as new pyrazole analogs of the left-hand segment of the potent natural antineoplastic agent CC-1065.

HETEROCYCLICALLY SUBSTITUTED TRIFLUOROMETHYLPYRIMIDINONES AND THEIR USE

The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Our investigation of the structure-activity and structure-liability relationships for dihydropyrrolopyrazol-6-one MCHR1 antagonists revealed that off-rate characteristics, inferred from potencies in a FLIPR assay following a 2 h incubation, can impact in