179897-94-0

Basic information

• Product Name: 5-Fluoro-2-methoxyphenylboronic acid
• Synonyms: RARECHEM AH PB 0134;AKOS BRN-0214;5-FLUORO-2-METHOXYBENZENEBORONIC ACID;5-FLUORO-2-METHOXYPHENYLBORONIC ACID;3-FLUORO-6-METHOXYBENZENEBORONIC ACID;2-METHOXY-5-FLUOROBENZENEBORONIC ACID;2-METHOXY-5-FLUOROPHENYLBORONIC ACID;CHEMBRDG-BB 4202998
• CAS NO: 179897-94-0
• Molecular Formula: C₇H₈BFO₃
• Molecular Weight: 169.95
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Substituted Boronic Acids;Boronic Acid;Alkoxy;Aryl;Organoborons;Boronic Acids;Boronic Acids and Derivatives;Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;Organometallic Reagents;Furans
• Mol File: 179897-94-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 144-153 °C(lit.)
• Boiling Point: 337.1 °C at 760 mmHg
• Flash Point: 157.6 °C
• Appearance: White/Crystalline Powder
• Density: 1.26 g/cm³
• Vapor Pressure: 2.08E-05mmHg at 25°C
• Refractive Index: 1.552
• Solubility: soluble in Methanol
• PKA: 7.52±0.58(Predicted)
• CAS DataBase Reference: 5-Fluoro-2-methoxyphenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-methoxyphenylboronic acid(179897-94-0)
• EPA Substance Registry System: 5-Fluoro-2-methoxyphenylboronic acid(179897-94-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36/37/39-36-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 179897-94-0(Hazardous Substances Data)

Usage

Description

5-Fluoro-2-methoxyphenylboronic acid is an organic compound that serves as a crucial building block in various organic syntheses. It is characterized by its white to off-white powdery appearance and is known for its role as a reagent in Suzuki coupling reactions and copper-catalyzed arylation reactions. Additionally, it has been identified as a bacterial mutagen, highlighting its potential applications in research and development.

Uses

Used in Organic Synthesis:
5-Fluoro-2-methoxyphenylboronic acid is used as a key building block in organic synthesis for the creation of various complex molecules and compounds. Its unique structure allows for the formation of new chemical bonds and the synthesis of a wide range of organic molecules.
Used in Suzuki Coupling Reactions:
In the field of chemistry, 5-Fluoro-2-methoxyphenylboronic acid is utilized as a reagent for Suzuki coupling reactions. These reactions are essential for the formation of carbon-carbon bonds, which are vital in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Copper-Catalyzed Arylation Reactions:
5-Fluoro-2-methoxyphenylboronic acid also plays a significant role in copper-catalyzed arylation reactions. These reactions are crucial for the synthesis of aromatic compounds, which are widely used in the chemical, pharmaceutical, and materials industries.
Used in Research and Development:
As a bacterial mutagen, 5-Fluoro-2-methoxyphenylboronic acid is employed in research and development for studying the effects of mutations on bacterial cells. This application is essential for understanding the mechanisms of bacterial resistance and the development of new antibiotics and antimicrobial agents.

InChI:InChI=1/C6H6BFO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9-11H

Upstream product

• 121-43-7 Trimethyl borate 
• 452-08-4 2-bromo-4-fluoro-1-methoxybenzene 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 713145-54-1 8-(5-fluoro-2-methoxy-phenyl)-[1,7]naphthyridin-6-ylamine 
• 259209-20-6 5-fluoro-2-hydroxyphenyl-boronic acid 
• 478035-73-3 2-(2,4-Dimethoxy-phenyl)-3,6-diethyl-5-(5-fluoro-2-methoxy-phenyl)-pyrazine 
• 179898-09-0 methyl (5'-fluoro-2'-methoxy-4-nitro-2-biphenyl)carboxylate 
• 1123158-89-3 5-bromo-5'-fluoro-2'-methoxy-biphenyl-3-ol 
• 1144520-05-7 C₁₈H₂₃FN₂O₄ 
• 1160431-24-2 Ethyl 1-(6-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 943153-04-6 1-(2-allyl-5'-fluoro-2'-methoxy-biphenyl-4-yl)-ethanone 
• 943152-67-8 5'-fluoro-3,2'-dimethoxy-biphenyl-4-carbaldehyde 
• 1183268-90-7 5'-fluoro-2'-methoxybiphenyl-2-carbaldehyde 
• 1261614-52-1 2,3,4,5,5',6-hexafluoro-2'-methoxy-1,1'-biphenyl 
• 1261861-90-8 2',3',4',5,5',6'-hexafluoro-[1,1'-biphenyl]-2-ol 
• 1549884-56-1 3,3''-((ethane-1,2-diylbis(methylazanediyl)) bis(methylene) )bis(2',3',4',5,5',6'hexafluoro-[1,1'-biphenyl]-2-ol) 
• 905912-70-1 4-bromomethyl-6-(5-fluoro-2-methoxy-phenyl)-2,2-dimethyl-1,2-dihydro-quinoline 

Relevant articles and documents

HALOGENATED CATALYSTS COMPRISING SALAN LIGANDS

Catalysts comprising a halogenated Salan ligand. Also disclosed are catalyst systems comprising the catalyst and an activator; methods to prepare the ligands, catalysts and catalyst systems; processes to polymerize olefins using the catalysts and/or catalyst systems; and the olefin polymers prepared according to the processes.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.