180298-85-5

Basic information

• Product Name: 2-[[2-(allylamino)-4-amino-1,3-thiazol-5-yl](phenyl)methylene]malononitrile
• Synonyms: 2-[[2-(allylamino)-4-amino-1,3-thiazol-5-yl](phenyl)methylene]malononitrile
• CAS NO: 180298-85-5
• Molecular Formula: C₁₆H₁₃N₅S
• Molecular Weight: 307.37292
• Mol File: 180298-85-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[[2-(allylamino)-4-amino-1,3-thiazol-5-yl](phenyl)methylene]malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[2-(allylamino)-4-amino-1,3-thiazol-5-yl](phenyl)methylene]malononitrile(180298-85-5)
• EPA Substance Registry System: 2-[[2-(allylamino)-4-amino-1,3-thiazol-5-yl](phenyl)methylene]malononitrile(180298-85-5)

Safety Data

• Hazardous Substances Data: 180298-85-5(Hazardous Substances Data)

Upstream product

• 4651-78-9 2-bromo-1-phenylethylidenemalononitrile 
• 61993-89-3 1-allyl-3-cyanothiourea sodium salt 
• 61993-89-3 1-allyl-3-cyano-thiourea; sodium salt 

Relevant articles and documents

2-Bromo-1-arylethylidenemalononitriles - Convenient reagents for the regioselective synthesis of fused pyridines

2-Bromo-1-arylethylidenemalononitriles react with conjugated thiolaronitriles to give products of regioselective S alkylation that can be subsequently involved in the Thorpe reaction. Resulting enaminoacrylonitriles form pyridine ring under base catalysis yielding thienodipyridines. According to this common scheme, functionally substituted thieno[3,2-b]pyridines, thiazolo[4,5-b]pyridines, thieno[3,2-b-4,5-h']dipyridines, their hydrogenated analogues, and pyrido[2',3':4,5]thieno[2.3-d]pyrimidine were synthesized.

2-Bromo-1-phenylethylidenemalononitrile in the synthesis of thieno[3,2-b]pyridines and thiazolo[4,5-b]pyridines

A novel regioselective synthesis of thieno[3,2-b]pyridines and thiazolo[4,5-b]pyridines from 2-bromo-1-phenylethylidenemalononitrile is proposed. In the case of the thiazolo[4,5-b]pyridines, the intermediate 5-(2,2-dicyano-1-phenylvinyl)thiazoles were separated. Formation of the thiazolo[4,5-b]pyridines was confirmed by x-ray analysis. 1996 Plenum Publishing Corporation.