180465-66-1

Basic information

• Product Name: C₂₈H₃₇N₃O₆S
• Synonyms: C₂₈H₃₇N₃O₆S
• CAS NO: 180465-66-1
• Molecular Weight: 543.684
• Mol File: 180465-66-1.mol
• Article Data: 5

Chemical Properties

• Density: 1.29±0.1 g/cm3(Predicted)
• CAS DataBase Reference: C₂₈H₃₇N₃O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₇N₃O₆S(180465-66-1)
• EPA Substance Registry System: C₂₈H₃₇N₃O₆S(180465-66-1)

Safety Data

• Hazardous Substances Data: 180465-66-1(Hazardous Substances Data)

Usage

General Description

"C28H37N3O6S" refers to the chemical formula of a compound consisting of 28 carbon atoms, 37 hydrogen atoms, 3 nitrogen atoms, 6 oxygen atoms, and 1 sulfur atom. C₂₈H₃₇N₃O₆S is likely a complex organic molecule, given the presence of carbon and hydrogen in its formula. The specific properties and uses of this compound cannot be identified without further information, as the chemical formula alone does not provide enough detail to determine its structure or function. Further analysis and testing would be needed to fully understand the nature of this chemical.

Upstream product

• 3262-72-4 (R)-N-tert-butoxycarbonyl serine 
• 100-63-0 phenylhydrazine 
• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6457-49-4 4-piperidinemethanol 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 
• 184289-84-7 benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 167484-18-6 benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 184289-85-8 benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 100-39-0 benzyl bromide 
• 498-94-2 isonipecotic acid 

Downstream Products

• 159634-87-4 N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide 
• 191487-52-2 MK-677 
• 159634-47-6 Ibutamoren 
• 180465-67-2 C₂₃H₂₉N₃O₄S 

Relevant articles and documents

A facile synthesis of the spiroindoline-based growth hormone secretagogue, MK-677

A facile and improved route for the synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 was described. The key step adopted the Fischer indole/reduction strategy. The preparation of the key intermediates N-protected piperidine carboxaldehyde 5 and the N-Boc-O-benzyl-d-serine (2) are also optimized.

THERAPEUTIC COMPOUNDS AND USES THEREOF

Compounds of formula (I) are described herein The compounds can be used, for example, to modulate growth hormone secretagogue receptor (GHS-R). In some instances, the compounds can be used to treat obesity.

Synthesis of the orally active spiroindoline-based Growth Hormone Secretagogue, MK-677

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall yield from isonipecotic acid 3.