180465-67-2

Basic information

• Product Name: C₂₃H₂₉N₃O₄S
• Synonyms: C₂₃H₂₉N₃O₄S
• CAS NO: 180465-67-2
• Molecular Weight: 443.567
• Mol File: 180465-67-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₉N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₉N₃O₄S(180465-67-2)
• EPA Substance Registry System: C₂₃H₂₉N₃O₄S(180465-67-2)

Safety Data

• Hazardous Substances Data: 180465-67-2(Hazardous Substances Data)

Upstream product

• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 100-63-0 phenylhydrazine 
• 6457-49-4 4-piperidinemethanol 
• 184289-84-7 benzyl 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 167484-18-6 benzyl spiro[indoline-3,4’-piperidine]-1‘-carboxylate 
• 184289-85-8 benzyl spiro[indole-3,4'-piperidine]-1'-carboxylate 
• 178261-41-1 1-(methylsulfonyl)spiro[indoline-3,4’-piperidine] 
• 10314-99-5 benzyl 4-(chlorocarbonyl)piperidine-1-carboxylate 
• 138163-08-3 N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde 
• 10314-98-4 1-benzyloxycarbonylpiperidine-4-carboxylic acid 
• 100-39-0 benzyl bromide 
• 498-94-2 isonipecotic acid 
• 159634-86-3 1-Methanesulfonyl-spiro[indoline-3,4'-piperidine] hydrochloride 
• 47173-80-8 N-Boc-D-serine(Bzl)-OH 

Downstream Products

• 159634-47-6 Ibutamoren 
• 191487-52-2 MK-677 
• 851977-26-9 C₂₅H₃₁N₃O₆S₂ 
• 851977-20-3 C₃₀H₄₀N₄O₅S 
• 159634-87-4 N-[(R)-[(1,2-Dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-[(1,1-dimethyl-ethoxy)carbonyl]amino-2-methyl-propanamide 

Relevant articles and documents

A facile synthesis of the spiroindoline-based growth hormone secretagogue, MK-677

A facile and improved route for the synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 was described. The key step adopted the Fischer indole/reduction strategy. The preparation of the key intermediates N-protected piperidine carboxaldehyde 5 and the N-Boc-O-benzyl-d-serine (2) are also optimized.

SULFONAMIDES AND USES THEREOF

Compounds of formulas (I), (II), (III), and (IV) and methods of treating disorders by administering a compound of formula (I), (II), (III), or (IV) are described herein. Examples of disorders include neoplastic disorders, fat-cell related disorders, neurodegenerative disorders, and metabolic disorders.

Synthesis of the orally active spiroindoline-based Growth Hormone Secretagogue, MK-677

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall yield from isonipecotic acid 3.