18091-89-9

Basic information

• Product Name: 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine
• Synonyms: 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine;(7-Chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)hydrazine;2-Hydrazino-5-phenyl-7-chloro-3H-1,4-benzodiazepine;7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one Hydrazone
• CAS NO: 18091-89-9
• Molecular Formula: C₁₅H₁₃ClN₄
• Molecular Weight: 284.74352
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 18091-89-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine(18091-89-9)
• EPA Substance Registry System: 7-Chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine(18091-89-9)

Safety Data

• Hazardous Substances Data: 18091-89-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Solid

Uses

Alprazolam intermediate.

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 79-04-9 chloroacetyl chloride 
• 4547-02-8 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione 
• 4340-86-7 7-chloro-2-methylmercapto-5-phenyl-3H-1,4-benzodiazepine 
• 7564-07-0 2-amino-7-chloro-5-phenyl-3H-1,4-benzodiazepine 

Downstream Products

• 63271-82-9 9-chloro-2-methyl-7-phenyl-1,5-dihydro-benzo[f][1,2,4]triazino[4,3-a][1,4]diazepine 
• 28981-97-7 alprazolam 
• 54304-85-7 8-Chloro-1-(bromomethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 28910-95-4 8-chloro-1,6-diphenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine 
• 39479-72-6 8-chloro-1-(chloromethyl)-6-phenyl-4H-s-triazolo<4,3-a><1,4>benzodiazepine 
• 29975-16-4 estazolam 
• 41212-87-7 7-chloro-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one ethylidenehydrazone 
• 60640-16-6 N-[2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-1-methyl-ethyl]-phthalimide 
• 72874-54-5 8-Chloro-6-phenyl-1-(3-pyrrolidin-1-yl-propyl)-4H-2,3,5,10b-tetraaza-benzo[e]azulene 
• 72874-51-2 [3-(8-Chloro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl)-propyl]-diethyl-amine 
• 72874-28-3 [3-(8-Chloro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulen-1-yl)-propyl]-dimethyl-amine 
• 37115-32-5 adinazolam 
• 62177-07-5 2-(8-chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-yl)-ethylamine 
• 72874-33-0 N-<2-<4-(2-benzoyl-4-chlorophenyl)-5-<(dimethylamino)methyl>-4H-1,2,4-triazol-3-yl>ethyl>phthalimide 

Relevant articles and documents

Electrochemical synthesis of 1,2,4-triazole-fused heterocycles

A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.

Benzodiazepine derivatives

Benzodiazepine derivatives of the general formula STR1 where R1 is hydrogen or a hydrocarbon residue of 1-8 carbon atoms, R2 is hydrogen or lower alkyl and rings A and B are unsubstituted or substituted by nitro, trifluoromethyl, halogen, lower alkyl or lower alkoxy, the nitrogen atom in the 5-position being unsubstituted or substituted by an oxygen atom, useful as muscle relaxants, anticonvulsants, sedatives and tranquilizing agents, and processes for production thereof. Also provided are novel intermediates of the general formula STR2 where R2 has the above meaning, rings A and B are unsubstituted or substituted as above and the nitrogen atom in the 4-position is unsubstituted or substituted by an oxygen atom.