18144-47-3

Basic information

• Product Name: tert-Butyl 4-aminobenzoate
• Synonyms: TERT-BUTYL 4-AMINOBENZOATE;4-AMINOBENZOIC ACID TERT-BUTYL ESTER;BUTTPARK 14\02-67;tert-butyl 4-azanylbenzoate;tert-Butyl 4-aminobe;4-(tert-Butoxycarbonyl)aniline;H-4-Abz-OtBu(Tert-butyl 4-AMinobenzoate);Tert-Butyl p-aMinobenzoate
• CAS NO: 18144-47-3
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• EINECS: 1312995-182-4
• Product Categories: API intermediates;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 18144-47-3.mol
• Article Data: 24

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 322.4 °C at 760 mmHg
• Flash Point: 173.6 °C
• Appearance: /
• Density: 1.078 g/cm³
• Vapor Pressure: 0.000279mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.43±0.10(Predicted)
• BRN: 2803178
• CAS DataBase Reference: tert-Butyl 4-aminobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-aminobenzoate(18144-47-3)
• EPA Substance Registry System: tert-Butyl 4-aminobenzoate(18144-47-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-34
• Hazardous Substances Data: 18144-47-3(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 4-aminobenzoate, also known as butamben, is a chemical compound with the formula C11H15NO2. It's an ester and a tertiary amine, used primarily as a local anesthetic. As an active ingredient in some topical and ophthalmic medications, it can provide pain relief by blocking sodium channels and therefore preventing nerve impulses. It is characterized by its off-white appearance and slight aromatic smell. Considering safety, it is generally considered low-hazard but can cause eye and skin irritation if not properly handled. Proper storage and disposal methods should be followed.

InChI:InChI=1/C11H15NO2/c1-11(2,3)14-10(13)8-4-6-9(12)7-5-8/h4-7H,12H2,1-3H3

Upstream product

• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 150-13-0 4-amino-benzoic acid 
• 1257310-84-1 4-(2-trimethylsilanylethoxycarbonylamino)benzoic acid tert-butyl ester 
• 16106-38-0 4-aminobenzoyl chloride 
• 75-65-0 tert-butyl alcohol 
• 769121-30-4 (4-acetylaminophenyl)carbamic acid tert-butyl ester 
• 1370363-00-0 4-aminobenzoic acid tert-butyl ester hydrochloride 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 
• 59247-47-1 tert-butyl-4-bromobenzoate 
• 24537-25-5 4-sulfinylamino-benzoyl chloride 

Downstream Products

• 94930-28-6 N-<4'-(tert-butoxycarbonyl)phenyl>-3-pyrrolidinol 
• 716361-86-3 (E)-1-[3'-(4''-t-butylbenzoyl)benzamido-4'-benzyloxy]phenyl-2-(3''',5'''-dibenzyloxy)phenylethene 
• 486415-37-6 tert-butyl 4-isothiocyanatobenzoate 
• 869366-13-2 tert-butyl 4-(2,3-bis(benzyloxycarbonyl)guanidino)benzoate 
• 893447-42-2 4-(2-cyclopropyl-5-phenylpyrazolo[1,5-a]pyrimidin-7-ylamino)benzoic acid tert-butyl ester 
• 900507-54-2 C₂₂H₂₇N₅O₂ 
• 150-13-0 4-amino-benzoic acid 
• 167767-27-3 4-[6,7-bis(palmitoyloxy)4-thiaheptanoylamino]benzoic acid t-butyl ester 
• 1146547-63-8 C₁₆H₁₇BrN₂O₂ 
• 1146547-58-1 tert-butyl 9H-pyrido-[2,3-b]indole-6-carboxylate 

Relevant articles and documents

Hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis

The invention relates to a hydroboration reduction reaction of aromatic nitro compounds without transition metal catalysis. According to the method, triethyl boron and potassium tert-butoxide are used as catalysts for the first time, and an aromatic nitro compound and pinacol borane which is low in price and easy to obtain can be conveniently catalyzed to be subjected to a hydroboration reduction reaction under mild conditions to prepare aromatic amine products. Compared with a traditional method, the method generally has the advantages that the catalyst is cheap and easy to obtain, operation is convenient, and reaction is safe. The selective hydroboration reduction reaction of the non-transition metal reagent catalyzed aromatic nitro compound and pinacol borane is realized for the first time, and a practical new reaction strategy is provided for laboratory preparation or industrial production of aromatic amine products.

Synergistic effects in Fe nanoparticles doped with ppm levels of (Pd + Ni). A new catalyst for sustainable nitro group reductions

A remarkable synergistic effect has been uncovered between ppm levels of Pd and Ni embedded within iron nanoparticles that leads to mild and selective catalytic reductions of nitro-containing aromatics and heteroaromatics in water at room temperature. NaBH4 serves as the source of inexpensive hydride. Broad substrate scope is documented, along with several other features including: low catalyst loading, low residual metal in the products, and recycling of the catalyst and reaction medium, highlight the green nature of this new technology.

SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS

The present disclosure relates to compounds having the Formula (Formula (I)) which are inhibitors of STAT5.