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Cas Database

1816-75-7

1816-75-7

Identification

  • Product Name:(3β,5α,17β)-Estrane-3,17-diol

  • CAS Number: 1816-75-7

  • EINECS:

  • Molecular Weight:278.435

  • Molecular Formula: C18H30O2

  • HS Code:

  • Mol File:1816-75-7.mol

Synonyms:(3S,5S,8R,9R,10S,13S,14S,17S)-13-methyl-1,2,3,4,5,6,7,8,9,10,11,12,14,15,16,17-hexadecahydrocyclopenta[a]phenanthrene-3,17-diol;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 5 Articles be found

An easy stereoselective synthesis of 5(10)-estrene-3β,17α-diol, a biological marker of pregnancy in the mare

Balssa, Frédéric,Fischer, Michael,Bonnaire, Yves

, p. 1 - 4 (2014/06/09)

5(10)-Estrene-3β,17α-diol is an essential reference material for doping analysis in horse-racing laboratories. It is used to detect misuse, for doping purpose, of the pregnancy status in the mare. Its stereoselective synthesis from 17β-estradiol-3-methyl ether (prepared from estrone or 17β-estradiol) was performed in four steps: (1) Mitsunobu inversion of the 17β-alcohol; (2) Birch reduction of the aromatic ring; (3) stereoselective reduction of the 3-ketone via Noyori asymmetric transfer hydrogenation; (4) chemoenzymatic purification.

PROGESTERONE RECEPTOR ANTAGONISTS AND USES THEREOF

-

Page/Page column 68-69, (2011/11/30)

The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.

Regioselectivity in the Hydroboration of Steroidal δ3-Allylic Alcohols

Alam, Muzaffar,Hanson, James R.,Liman, Mansur,Nagaratnam, Sivajini

, p. 56 - 57 (2007/10/03)

The presence of an allylic 5α-hydroxy group in an androst-3-ene increases the proportion of addition of a borane to the adjacent C-4 compared to the unsubstituted steroid and directs the addition to the face of the alkene anti to the hydroxy group with stereochemical effects that may oppose those of the C-10β-methyl group.

Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors

Han, Mingcheng,Zorumski, Charles F.,Covey, Douglas F.

, p. 4218 - 4232 (2007/10/03)

A series of analogues of the neuroactive steroids 3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one were studied to elucidate the mode of binding of 5α- and 5β-reduced steroids to steroid binding sites on GABA(A) receptors. Analogues which were either 3α-hydroxy-20-ketosteroids or 3α-hydroxysteroid-17β-carbonitriles and which contained various methyl group substitution patterns at C-5 and C-10 were prepared. Evaluations utilized whole-cell patch clamp electrophysiological methods carried out on cultured rat hippocampal neurons, and the results obtained with the rigid 17β-carbonitrile analogs were analyzed using molecular modeling methods. The molecular modeling results provide a rationale for the observation that the configuration of the hydroxyl group at C-3 is a greater determinant of anesthetic potency than the configuration of the A,B ring fusion at C-5. The electrophysiological results identify steric restrictions for the space that can be occupied in 5α- and 5β-reduced steriod modulators of GABA(A) recepters in the regions of space proximate to the steroid C-5, C-10, and possibly C-4 positions. This information is useful for the development of nonsteroidal analogues that can modulate GABA(A) receptors via interactions at steroid binding sites.

Microbiological Transformations. XIII. Transformations of 19-Nor and 19-Hydroxy Analogues of Testosterone and Androstendione by Means of Rhodotorula mucilaginosa Strain

Dmochowska-Gladysz, Jadwiga,Tlomak, Elzbieta,Siewinski, Antoni

, p. 1 - 8 (2007/10/02)

Preparative transformation carried out

Process route upstream and downstream products

Process route

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5α‐estrane‐3α,17β‐diol
10002-95-6

5α‐estrane‐3α,17β‐diol

5α‐estrane‐3β,17β‐diol
1816-75-7

5α‐estrane‐3β,17β‐diol

19-Norandrosterone
1225-01-0

19-Norandrosterone

19-nor-5α-androstan-3β-ol-17-one
10002-93-4

19-nor-5α-androstan-3β-ol-17-one

Conditions
Conditions Yield
for 336h; Further byproducts given; Rhodotorula mucilaginosa;
15%
18%
30%
15%
19-nortestosterone
434-22-0

19-nortestosterone

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5α‐estrane‐3β,17β‐diol
1816-75-7

5α‐estrane‐3β,17β‐diol

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

Conditions
Conditions Yield
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yields of byproduct given; Ambient temperature;
16%
7%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Title compound not separated from byproducts; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yield given; Ambient temperature;
7%
16%
Conditions
Conditions Yield
Oestr-5(10)-en-3β,17β-diol 6b, Ru-oxid, Hydrierung;
5(10)-Estren-3-on-17β-ol, RuO2/H2;
Estran, RuO2/H2;
Conditions
Conditions Yield
Oestratrien-(A)-diol, Rutheniumdioxyd, A., wenig wss. NaOH, 65grad, 100 at, Hydrieren, neben 5α,10α-Oestradiol-(3β,17β);
Oestr-5(10)-en-3α,17β-diol, H2, Ru-oxid, neben sehr wenig 5β-Estran-3α,17β-diol;
Oestr-5(10)-en-3α,17β-diol, H2, Rhodium-Aluminium, neben sehr wenig 5β-Estran-3α,17β-diol;
Conditions
Conditions Yield
19-Norandrosten-17β-ol-3-on, NaBH4;
19-Nor-androstandion-(3,17), NaBH4, wss. Propanol-(2), Me., neben 3β-Hydroxy-19-nor-androstanon-(17);
Conditions
Conditions Yield
5β-Oestrandiol-(3α,17β)-acetat-(17β), Me., wenig W., KOH, Kochen;
5β-Oestranol-(3α)-on-(17), NaBH4, Stehenlassen;

Global suppliers and manufacturers

Global( 2) Suppliers
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  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
  • NovaChemistry
  • Business Type:Trading Company
  • Contact Tel:+44 (0)208 191 7890
  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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