181822-84-4

Basic information

• Product Name: Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester
• Synonyms: Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester
• CAS NO: 181822-84-4
• Molecular Weight: 453.519
• Mol File: 181822-84-4.mol

Chemical Properties

• CAS DataBase Reference: Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester(181822-84-4)
• EPA Substance Registry System: Acetic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester(181822-84-4)

Safety Data

• Hazardous Substances Data: 181822-84-4(Hazardous Substances Data)

Upstream product

• 181823-27-8 2-(2,4-Dimethoxy-benzylsulfanyl)-nicotinic acid 
• 14045-17-1 4-amino-2-methylpyridine N-oxide 

Downstream Products

• 181822-83-3 2-(2,4-Dimethoxy-benzylsulfanyl)-N-(2-hydroxymethyl-pyridin-4-yl)-nicotinamide 
• 1025988-60-6 2-[(2,4-dimethoxybenzyl)thio]-N-(2-propionyloxymethyl-4-pyridinyl)pyridine-3-carboxamide 
• 1026263-46-6 Butyric acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester 
• 1026522-57-5 Pentanoic acid 4-{[2-(2,4-dimethoxy-benzylsulfanyl)-pyridine-3-carbonyl]-amino}-pyridin-2-ylmethyl ester 

Relevant articles and documents

Nicotinamide derivatives as a new class of gastric (H+/K+)-ATPase inhibitors. II. Synthesis and structure-activity relationships of 2-[(2,4- dimethoxyhenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides

Members of a new series of 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(4- pyridinyl)pyridine-3-carboxamides were synthesized and evaluated for their gastric antisecretory activity and the ability to inhibit cytochrome P450- dependent O-dealkylation of 7-ethoxycoumarin (7-EC) in rat liver microsomes. Several of the compounds synthesized exhibited potent inhibitory activities against both [14C]aminopyrine accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells and histamine-induced gastric acid secretion in pylorus-ligated rats when administered intraduodenally; their inhibitory activities were equivalent to or superior to those of the parent compound [2[(2,4-dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3- carboxamide] and omeprazole. Among the compounds having potent antisecretory activity in vitro and in vivo, 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(2,5- dimethyl-4-pyridinyl)pyridine-3-carboxamide and 2-[(2,4- dimethoxybenzyl)sulfinyl]-N-(2,6-dimethyl-4-pyridinyl)pyridine-3-carboxamide in particular showed lower inhibitory activity against the 7-EC deethylase than omeprazole. It seems probable that, unlike omeprazole, these compounds do not interact with a metabolism of other drugs in vivo. These compounds, therefore, are considered to be more promising candidate agents for treating acid-related gastrointestinal disorders than the parent compound reported previously.