18226-17-0

Basic information

• Product Name: 2,2'-[(4-nitrophenyl)imino]bisethanol
• Synonyms: 2,2'-[(4-nitrophenyl)imino]bisethanol;2,2'-(4-Nitrophenylimino)diethanol;2,2'-(4-Nitrophenylazanediyl)diethanol;N-(4-Nitrophenyl)diethanolamine;Ethanol, 2,2'-[(4-nitrophenyl)iMino]bis-;2-[(2-hydroxyethyl)(4-nitrophenyl)amino]ethan-1-ol
• CAS NO: 18226-17-0
• Molecular Formula: C₁₀H₁₄N₂O₄
• Molecular Weight: 226.22916
• EINECS: 242-104-0
• Mol File: 18226-17-0.mol
• Article Data: 26

Chemical Properties

• Melting Point: 101-102 °C
• Boiling Point: 451.7°Cat760mmHg
• Flash Point: 227°C
• Appearance: /
• Density: 1.352g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.15±0.10(Predicted)
• CAS DataBase Reference: 2,2'-[(4-nitrophenyl)imino]bisethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-[(4-nitrophenyl)imino]bisethanol(18226-17-0)
• EPA Substance Registry System: 2,2'-[(4-nitrophenyl)imino]bisethanol(18226-17-0)

Safety Data

• Hazardous Substances Data: 18226-17-0(Hazardous Substances Data)

Usage

General Description

"2,2'-[(4-nitrophenyl)imino]bisethanol" is a chemical compound also known as Nitrobenzene Diethanolamine. It is a pale yellow liquid with a molecular formula C14H14N2O6. 2,2'-[(4-nitrophenyl)imino]bisethanol is commonly used as a chemical intermediate in the production of pharmaceuticals, organic synthesis, and various other applications. Its properties include being corrosive to the eyes and skin, and it may cause irritation upon contact. It is important to handle this chemical with care and follow proper safety protocols when working with it.

Upstream product

• 75-21-8 oxirane 
• 100-01-6 4-nitro-aniline 
• 100-00-5 4-chlorobenzonitrile 
• 111-42-2 2,2'-iminobis[ethanol] 
• 18226-07-8 4-nitro-N,N-bis(2-hydroxyethyl)benzenesulfonamide 
• 350-46-9 4-Fluoronitrobenzene 
• 113342-93-1 1-(4-Nitro-phenyl)-2,5-dihydro-1H-pyrrole 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 24813-13-6 N,N-di(2-chloroethyl)-3-nitrobenzeneamine 
• 55743-71-0 bis(2-chloroethyl)(4-nitrophenyl)amine 
• 23721-18-8 N,N-bis<2-<(methylsulfonyl)oxy>ethyl>-4-nitroaniline 
• 304015-61-0 N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline 
• 245125-18-2 13-(4-nitrophenyl)-1,4,7,10-tetraoxa-13-azacyclopentadecane 
• 13686-19-6 N¹,N¹-bis(2-chloroethyl)benzene-1,3-diamine 
• 122567-47-9 N,N-bis(2-bromoethyl)-4-nitroaniline 
• 135840-79-8 4-Nitro-[N,N-bis(2-acetoxyethyl)]aniline 
• 528836-36-4 4-(N'-benzyloxycarbonyl)amino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline 
• 528836-37-5 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline 
• 244247-70-9 4-bis(2'-tert-butyldimethylsilyloxyethyl)amino-N-tert-butyloxycarbonylaniline 
• 528836-53-5 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-mesyloxyethyl)aniline 
• 528836-38-6 4-methylamino-N,N-bis[2'-(tert-butyldimethylsilyloxy)ethyl]aniline 
• 528836-52-4 ((4-((tert-butoxycarbonyl)amino)phenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate 

Relevant articles and documents

A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells

Herein, a novel soluble mitochondria-targeted theranostic compound, HMX-1, was presented, which was selectively activated under hypoxia with excellent mitochondria-targeting ability at the cellular level, accompanied by a dramatic increase in the fluorescence intensity. Moreover, its anti-cancer efficiency was certified both in vitro and in vivo.

Synthesis and antiproliferative activity of some new DNA-targeted alkylating pyrroloquinolines

Two novel DNA-direct alkylating agents, consisting of aniline mustard linked to an angular 3H-pyrrolo[3,2-f]quinoline nucleus, were synthetized and assayed for their in vitro antiproliferative activity. Simple convergent synthesis, consisting of separate preparation of 9-chloro-3H-pyrrolo[3,2-f] quinoline and p-amino-aniline derivatives, and following their linkage by substitution reactions 8a, b and 10, yielded the corresponding diol derivatives 7b and 9. Biological properties were evaluated with respect to cell growth inhibition, ability to form cross-links with DNA, and capacity to give rise to a molecular complex with the macromolecule for 7b, 8b, 9 and 10.

Cyanine-based fluorescent indicator for mercury ion and bioimaging application in living cells

A commercial cyanine dye IR-780 and a thioether-containing dicarboxylic acid ligand were used to construct the near-infrared fluorescent probe, which was used as a near-infrared fluorescent indicator for the determination of mercury ions in water and in living cells. This indicator displayed high specificity towards Hg2+ without any interference from other detecting species. Especially, the emission at 790 nm dramatically increased more than 25 times after interacting with Hg2+. The binding experiment showed that the indicator formed 1:1 complex with Hg2+. More, this indicator could be applied in the visualization of Hg2+ in living cells and measuring the Hg2+ concentration of tap-water sample.

N nitrogen mustard derivatives, two N - (2 - chloroethyl) - 1, 4 - phenylenediamine - N' - sixteen-acyl and its preparation method

The invention discloses a structural formula of a nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine, and a preparation method thereof. The preparation method comprises the following steps: preparing N,N-di(2-chloroethyl)-1,4-phenylenediamine; putting the reaction raw materials comprising the N,N-di(2-chloroethyl)-1,4-phenylenediamine, dichloromethane and triethylamine into a reactor, cooling in ice-water bath, stirring, dropwise adding a mixed solution of hexadecanoyl chloride and dichloromethane into the reactor, removing the ice-water bath after addition, conducting reaction at room temperature for 12 to 14 hours, sequentially performing washing, drying and normal-pressure distillation on the reaction liquid after the reaction is conducted completely, and purifying the distilled filter cake to obtain the product. The arylamine nitrogen mustard derivative provided by the invention can effectively reduce the toxic and side effects of nitrogen mustard on the premise of enhancing the treatment index of the nitrogen mustard, and has sterilization and inflammation-diminishing curative effects to reduce the risk of complication caused by the fact that the immunity is reduced after a patient is subjected to chemical therapy.