182318-00-9

Basic information

• Product Name: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one
• Synonyms: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one
• CAS NO: 182318-00-9
• Molecular Weight: 313.359
• Mol File: 182318-00-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one(182318-00-9)
• EPA Substance Registry System: 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one(182318-00-9)

Safety Data

• Hazardous Substances Data: 182318-00-9(Hazardous Substances Data)

Usage

General Description

1-(1H-benzo[d][1,2,3]triazol-1-yl)-2,2-diphenylethan-1-one, also known as BTT-1023, is a synthetic compound that belongs to the class of organic compounds known as benzotriazoles. It is a diphenylethanone derivative and has a chemical structure that includes a benzotriazole ring attached to a diphenylethanone moiety. BTT-1023 has demonstrated potential pharmaceutical properties and has been studied for its potential use in the treatment of various diseases, including autoimmune conditions and cancer. It has shown promising immunosuppressive and anti-inflammatory effects in preclinical studies, making it a compound of interest for further research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 3826-49-1 Diphenyl-acetylfluorid 
• 117-34-0 2,2-diphenylacetic acid 
• 37073-15-7 1-(methanesulfonyl)-1H-1,2,3-benzotriazole 

Downstream Products

• 4107-00-0 2,2-diphenyl-1-(piperidin-1-yl)ethanone 
• 776296-99-2 ethyl 2-methyl-3-oxo-4,4-diphenylbutanoate 
• 4695-13-0 2,2-diphenylacetamide 
• 4695-14-1 2,2-diphenylacetanilide 

Relevant articles and documents

Sulfur–Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates

Amide bond formation is one of the most executed reactions in chemistry and biology. This is largely due to the ubiquity of the amide functional group in biological molecules, natural products and pharmaceutically important drugs. We report here the development of “SuFExAmide”: a new sulfur–fluoride exchange (SuFEx) click chemistry based protocol for the efficient amidation of carboxylic acids via acyl fluoride intermediates. We have developed benzene-1,3-disulfonyl fluoride as a cost effective, powerful and versatile coupling agent, which delivers challenging secondary and tertiary amides in excellent yields from sterically hindered and electron-deficient amines. The straightforward method offers significant benefits over existing protocols in terms of substrate scope, efficiency and ease of operation and is demonstrated by the synthesis of 44 amides, including GNF6702, an antiprotozoal drug candidate. In the majority of cases, the amide products are obtained in high yield without the need for excess reagents or chromatographic purification.