18300-37-3Relevant articles and documents
The α-effect in iminium ion catalysis
Cavill, Julie L.,Elliott, Richard L.,Evans, Gareth,Jones, Ian L.,Platts, James A.,Ruda, Antonio M.,Tomkinson, Nicholas C. O.
, p. 410 - 421 (2006)
The α-effect can be used as an effective means to promote iminium ion catalysed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure-activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Molecular modelling investigations provide a mechanistic rationale to the results observed.
