183478-96-8

Basic information

• Product Name: Acetamide, N-[2-amino-1-[(3-fluorophenyl)methyl]-1-methyl-2-thioxoethyl]-, (S)-
• CAS NO: 183478-96-8
• Molecular Formula: C12H15FN2OS
• Molecular Weight: 254.328
• Mol File: 183478-96-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetamide, N-[2-amino-1-[(3-fluorophenyl)methyl]-1-methyl-2-thioxoethyl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-amino-1-[(3-fluorophenyl)methyl]-1-methyl-2-thioxoethyl]-, (S)-(183478-96-8)
• EPA Substance Registry System: Acetamide, N-[2-amino-1-[(3-fluorophenyl)methyl]-1-methyl-2-thioxoethyl]-, (S)-(183478-96-8)

Safety Data

• Hazardous Substances Data: 183478-96-8(Hazardous Substances Data)

Upstream product

• 183478-90-2 (S)-2-Acetylamino-3-(3-fluoro-phenyl)-2-methyl-propionic acid 
• 183478-94-6 (S)-2-Acetylamino-3-(3-fluoro-phenyl)-2-methyl-propionamide 
• 183478-92-4 (S)-4-(3-Fluoro-benzyl)-2,4-dimethyl-4H-oxazol-5-one 
• 130855-56-0 (S)-2-amino-2-methyl-3-(3-fluorophenyl)propionic acid 
• 183478-91-3 N-[(S)-1-Cyano-2-(3-fluoro-phenyl)-1-methyl-ethyl]-acetamide 

Downstream Products

• 183478-98-0 N-acetyl-1-(3-fluorophenyl)-2-methyl-2-(2-thiazolyl)ethylamine 

Relevant articles and documents

Enantioselective synthesis of α,α-disubstituted amino acid derivatives via enzymatic resolution: Preparation of a thiazolyl-substituted α-methyl α-benzyl amine

A new and efficient enantioselective synthesis of the (S)-α,α-disubstituted phenethylamine 1 via Lipase resolution of the esters 3 and 4 is described. The effect of pH, enzyme load, and solubilizing additives has been studied and optimized. Conversion of the carboxylic acid 10 to the desired thiazole 1 is accomplished in high overall yield via an intermediate oxazolinone 13. This facile process requires only a single chromatographic step, and multigram quantities of 1 have been prepared.