183625-22-1Relevant articles and documents
Enantioselective synthesis of α,α-disubstituted amino acid derivatives via enzymatic resolution: Preparation of a thiazolyl-substituted α-methyl α-benzyl amine
Spero, Denice M.,Kapadia, Suresh R.
, p. 7398 - 7401 (2007/10/03)
A new and efficient enantioselective synthesis of the (S)-α,α-disubstituted phenethylamine 1 via Lipase resolution of the esters 3 and 4 is described. The effect of pH, enzyme load, and solubilizing additives has been studied and optimized. Conversion of the carboxylic acid 10 to the desired thiazole 1 is accomplished in high overall yield via an intermediate oxazolinone 13. This facile process requires only a single chromatographic step, and multigram quantities of 1 have been prepared.
