184177-88-6

Basic information

• Product Name: tert-butyl 2-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]hydrazinecarboxylate
• Synonyms: hydrazinecarboxylic acid, 2-[(1S,2S)-1-ethyl-2-(phenylmethoxy)propyl]-, 1,1-dimethylethyl ester; tert-Butyl 2-[(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazinecarboxylate
• CAS NO: 184177-88-6
• Molecular Formula: C₁₇H₂₈N₂O₃
• Molecular Weight: 308.4158
• Mol File: 184177-88-6.mol
• Article Data: 4

Chemical Properties

• Density: 1.031g/cm³
• Refractive Index: 1.501
• CAS DataBase Reference: tert-butyl 2-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]hydrazinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]hydrazinecarboxylate(184177-88-6)
• EPA Substance Registry System: tert-butyl 2-[(1S,2S)-2-(benzyloxy)-1-ethylpropyl]hydrazinecarboxylate(184177-88-6)

Safety Data

• Hazardous Substances Data: 184177-88-6(Hazardous Substances Data)

Usage

Uses

[S-(R*,R*)]-2-[1-ethyl-2-(phenylmethoxy)propyl]-1,1-dimethylethyl Ester Hydrazinecarboxylic Acid is used as a reagent in the preparation of triazolones.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 183871-36-5 C₁₂H₂₀N₂O*C₁₈H₁₄O₈ 
• 132489-33-9 (S)-2-benzyloxy-3-pentanone 
• 122151-32-0 (S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one 
• 183871-36-5 C₁₂H₂₀N₂O*C₁₈H₁₄O₈ 
• 183871-36-5 C₁₂H₂₀N₂O*C₁₈H₁₄O₈ 

Relevant articles and documents

Intermediate for preparing posaconazole

The invention discloses an intermediate POP for preparing posaconazole. A structure of the intermediate is as shown in the specification. By using the intermediate to prepare POB, the obtained POB hasa diastereomer content being smaller than or equal to 0.01%, and the total yield of the overall route is relatively high.

Preparation method of posaconazole intermediate

The invention discloses a preparation method of a key intermediate POB for preparing posaconazole. Firstly, BP004b04 and oxalic acid are salified to obtain POE; secondly, the POE reacts with di-tert-butyl dicarbonate in the presence of a base to obtain POP, and the POP is recrystallized; thirdly, the POP and POK react with each other in the presence of a base to obtain POR, and POS is obtained after a tert-butyl carbonate protecting group of the POR is removed; finally, the POS is subjected to ring closure to obtain the POB. By means of the method, in the obtained POB, the content of diastereomers is smaller than or equal to 0.01%, and the total yield of the entire route is high.