1849-54-3

Basic information

• Product Name: 3-Hydroxypyridine-4-carboxaldehyde
• Synonyms: 3-HYDROXY-ISONICOTINALDEHYDE;3-HYDROXY-PYRIDINE-4-CARBALDEHYDE;3-HYDROXYPYRIDINE-4-CARBOXALDEHYDE;4-FORMYL-3-HYDROXYPYRIDINE;4-Formyl-3-hydroxypyridine 3-Hydroxy-isonicotinaldehyde;3-Hydroxy-4-pyridinecarboxaldehyde;3-Hydroxypyridin-4-carbaldehyde;4-Pyridinecarboxaldehyde, 3-hydroxy-
• CAS NO: 1849-54-3
• Molecular Formula: C₆H₅NO₂
• Molecular Weight: 123.11
• Product Categories: Pyridines;Heterocycle-Pyridine series
• Mol File: 1849-54-3.mol

Chemical Properties

• Melting Point: 126-128 °C
• Boiling Point: 323.835 °C at 760 mmHg
• Flash Point: 149.65 °C
• Appearance: /
• Density: 1.327 g/cm³
• Vapor Pressure: 0.000135mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: pK1:4.05(＋1);pK2:6.77(OH) (25°C)
• CAS DataBase Reference: 3-Hydroxypyridine-4-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hydroxypyridine-4-carboxaldehyde(1849-54-3)
• EPA Substance Registry System: 3-Hydroxypyridine-4-carboxaldehyde(1849-54-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25
• Hazardous Substances Data: 1849-54-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Hydroxypyridine-4-carboxaldehyde is used as a key intermediate in the synthesis of pharmaceuticals, particularly for the production of antihistamines and anti-inflammatory drugs. Its unique structure allows for the development of new therapeutic agents with improved efficacy and safety profiles.
Used in Agrochemical Industry:
3-Hydroxypyridine-4-carboxaldehyde also serves as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products. Its versatility in chemical reactions enables the creation of novel agrochemicals with enhanced performance and selectivity.
Used in Organic Synthesis:
3-Hydroxypyridine-4-carboxaldehyde is utilized as a building block in the synthesis of various organic compounds, including dyes, polymers, and other specialty chemicals. Its reactivity and functional groups make it a valuable component in the design and synthesis of complex organic molecules.
Used in Biological Research:
3-Hydroxypyridine-4-carboxaldehyde has been studied for its potential biological activities, such as antioxidant and cytotoxic properties. Its presence in biological assays and screenings aids in understanding its role in various biological processes and its potential as a therapeutic agent.

InChI:InChI=1/C6H5NO2/c8-4-5-1-2-7-3-6(5)9/h1-4,9H

Upstream product

• 666234-13-5 3-methoxymethoxypyridine-4-carbaldehyde 
• 109-00-2 3-HYDROXYPYRIDINE 
• 81245-25-2 3-(methoxymethoxy)pyridine 

Downstream Products

• 1609986-27-7 C₁₅H₁₄N₂O₆ 
• 1609986-32-4 (3-((4,5-dimethoxy-2-nitrobenzyl)oxy)pyridin-4-yl)methanol 
• 1609986-39-1 C₂₆H₂₀F₃N₃O₉ 
• 67992-21-6 7-Azacoumarin 
• 830317-02-7 4-(p-tolylimino-methyl)-pyridin-3-ol 

Relevant articles and documents

NOVEL IMINONITRILE DERIVATIVES

The invention relates to a compound of formula (I) wherein X1 to X4 and RC to RG are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

INHIBITORS OF THE KYNURENINE PATHWAY

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.