185057-49-2

Basic information

• Product Name: 1-CBZ-3-BOC-AMINO PYRROLIDINE
• Synonyms: 1-CBZ-3-BOC-AMINO PYRROLIDINE;3-(Boc-aMino)-1-Cbz-pyrrolidine
• CAS NO: 185057-49-2
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.17
• Mol File: 185057-49-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 458.496 °C at 760 mmHg
• Flash Point: 231.091 °C
• Appearance: /
• Density: 1.174 g/cm³
• CAS DataBase Reference: 1-CBZ-3-BOC-AMINO PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CBZ-3-BOC-AMINO PYRROLIDINE(185057-49-2)
• EPA Substance Registry System: 1-CBZ-3-BOC-AMINO PYRROLIDINE(185057-49-2)

Safety Data

• Hazardous Substances Data: 185057-49-2(Hazardous Substances Data)

Usage

General Description

1-Cbz-3-Boc-amino pyrrolidine is a chemical compound that belongs to the class of pyrrolidines and is commonly used in organic synthesis. It is a derivative of pyrrolidine that has a benzyl carbamate (Cbz) and a tert-butoxycarbonyl (Boc) protecting group attached to the amino group of the pyrrolidine ring. These protecting groups allow for selective manipulation of the amino group in chemical reactions. 1-Cbz-3-Boc-amino pyrrolidine is used as a precursor in the preparation of various pharmaceuticals and diverse organic compounds due to its versatile reactivity and functional groups. It is a valuable building block in the synthesis of complex organic molecules.

Upstream product

• 99724-19-3 3-(tert-butoxycarbonylamino)pyrrolidine 
• 501-53-1 benzyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 68471-57-8 2,3-dihydro-pyrrole-1-carboxylic acid benzyl ester 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 185057-50-5 (S)-3-Amino-1-pyrrolidinecarboxylic acid,phenylmethyl ester 

Downstream Products

• 1159822-27-1 1-Cbz-3-aminopyrrolidine hydrochloride 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 
• 122536-77-0 3-N-tert-butoxycarbonyl-3-(R)-aminopyrrolidine 
• 185057-51-6 3-Amino-pyrrolidine-1-carboxylic acid benzyl ester trifluoroacetate 

Relevant articles and documents

Synthesis of β-Diamine Building Blocks by Photocatalytic Hydroamination of Enecarbamates with Amines, Ammonia and N?H Heterocycles

3-Amino-substituted saturated nitrogen heterocycles are an important subclass of β-diamines, appearing in a number of clinical agents. Herein, we report a unified approach to these products based upon the regioselective photoredox-mediated hydroamination of enecarbamates. The amine coupling partner can encompass diverse amine types under a single set of reaction conditions, including primary alkyl amines, ammonia, aryl and heteroaryl amines, and N?H heterocycles. The method enables the synthesis of a wide range of pharmaceutically relevant building blocks.

AMIDE DERIVATIVE

The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, -(CH2)sO-, - (CH2)sN(R4)CO-, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

Antithrombotic agents

This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well a