185105-98-0

Basic information

• Product Name: Acotiamide INT
• Synonyms: Acotiamide INT;Acotiamide Related Compound 12;ethyl 2-(2,4,5-trimethoxybenzamido)thiazole-4-carboxylate;2-((2,4,5-trimethoxybenzoyl)amino)-4-thiazolecarboxylic acid ethyl ester;2-[N-(2,4,5-trimethoxybenzoyl)amino]-4-ethoxycarbonyl-1,3-thiazole;2-[N- (2,4,5- trimethoxy benzoyl)]-4- amino ethoxy carbonyl -1,3- thiazole
• CAS NO: 185105-98-0
• Molecular Formula: C₁₆H₁₈N₂O₆S
• Molecular Weight: 366.38892
• Mol File: 185105-98-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.320±0.06 g/cm3(Predicted)
• PKA: 7.26±0.50(Predicted)
• CAS DataBase Reference: Acotiamide INT(CAS DataBase Reference)
• NIST Chemistry Reference: Acotiamide INT(185105-98-0)
• EPA Substance Registry System: Acotiamide INT(185105-98-0)

Safety Data

• Hazardous Substances Data: 185105-98-0(Hazardous Substances Data)

Usage

Uses

Ethyl 2-?(2,?4,?5-?Trimethoxybenzamido)?thiazole-?4-?carboxylate is an impurity of Acotiamide (A190260), an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

Upstream product

• 5398-36-7 2-aminothiazole-4-carboxylate 
• 490-64-2 asaronic acid 
• 70-23-5 ethyl Bromopyruvate 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 

Downstream Products

• 1809272-85-2 2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid 
• 185106-16-5 Acotiamide 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 

Relevant articles and documents

Preparation method of acotiamide hydrochloride impurity

The invention discloses a preparation method of an acotiamide hydrochloride impurity, which comprises the following steps: carrying out acylating chlorination on raw material 2, 4, 5-trimethoxybenzoicacid to obtain 2, 4, 5-trimethoxybenzoyl chloride, and

Industrial production method of acotiamide hydrochloride

The invention discloses an industrial production method of acotiamide hydrochloride. The industrial production method comprises the following steps that firstly, 2,4,5-trimethoxy benzoic acid serves as an initial raw material, acylating chlorination is ca

Preparation method of acotiamide intermediate

The invention belongs to the field of medicines, and concretely relates to a preparation method of an acotiamide intermediate. The method comprises the following steps: preparing acyl chloride from 2,4,5-trimethoxybenzoic acid, condensing acyl chloride an