186544-80-9

Basic information

• Product Name: C₂₂H₂₃N₃O₄S
• Synonyms: C₂₂H₂₃N₃O₄S
• CAS NO: 186544-80-9
• Molecular Weight: 425.508
• Mol File: 186544-80-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₃N₃O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₃N₃O₄S(186544-80-9)
• EPA Substance Registry System: C₂₂H₂₃N₃O₄S(186544-80-9)

Safety Data

• Hazardous Substances Data: 186544-80-9(Hazardous Substances Data)

Upstream product

• 105627-79-0 isoquinoline-5-sulfonyl chloride hydrochloride 
• 117009-97-9 benzyl 1,4-diazepane-1-carboxylate 
• 18158-16-2 benzyl 5-oxo-1,4-diazepane-1-carboxylate 
• 1208098-44-5 benzyl 4-(hydroxyimino)piperidine-1-carboxylate 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 105628-07-7 fasudil hydrochloride 

Relevant articles and documents

Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided

An efficient, robust, and cost-effective synthetic process of fasudil hydrochloride 1 was developed. Starting from readily available ethylenediamine and 5-isoquinoline sulfonyl chloride, the target product 1 was prepared through a six-step reaction, including sulfonamidation, protection, nucleophilic substitution, deprotection, cyclization, and salification. The process afforded 1 in 67.1% overall yield (based on 5-isoquinoline sulfonyl chloride) with 99.94% purity. Compared to the earlier published methodologies, the use of homopiperazine or its derivatives as intermediates was avoided. The salient features of this environmentally friendly synthetic route include easily available starting materials and operational simplicity, which could be suitable for large-scale industrial production.