1871-67-6Relevant articles and documents
Reaction of a lysyl residue analogue with E-2-octenal
Alaiz, Manuel,Barragan, Santiago
, p. 43 - 50 (1995)
The reaction of E-2-octenal and N2-(carbobenzyloxy)-L-lysine was investigated and the products analyzed to identify the components that produce a significant loss of lysine residues in the reaction of E-2-octenal and proteins. When the mixture of N2-(carbobenzyloxy)-L-lysine and E-2-octenal was incubated at pH 7.0 and 37 deg C for 24 h, seven products were isolated, and their structures are suggested to be E-2-octenoic acid (4), 4-butyl-E-2-E-4-E-6-dodecatrien-1-al (3), 6-ethyl-5-pentyl-1,3-cyclohexadiene (1), 3,8-dibutyl-1-(2'-butyl-4'-formyl-1'-E-3'-E-butadien-1'-yl) -5-pentyl-2,6-dihydronaftalene (2), 1-(N2-(carbobenzyloxy)-L-lysyl)-2-(1'-carboxymethyl)-4-pentylpyridinium betaine (6), 1-(N2-(carbobenzyloxy)-L-lysyl)-2-(3'-carboxy-2'-E-propen-1'-yl)-4-pentylpyridinium betaine (7) and bis(1-(N2-(carbobenzyloxy)-L-lysyl)-2-(3'-carboxy-2'-propen-1',2'-diyl)-4-pentylpyridinium betaine) (5). Plausible mechanisms for the formation of those compounds are proposed. Keywords: N2-(Carbobenzyloxy)-L-lysine; E-2-Octenal; Pyridinium salts; Reaction
Method for preparing alpha, beta-unsaturated carboxylic acid by reacting alkenyl boron compound with carbon dioxide under catalysis of cuprous halide
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Paragraph 0061-0062, (2020/06/17)
The invention discloses a method for preparing alpha, beta-unsaturated carboxylic acid through a carboxylation reaction of an alkenyl boron compound and carbon dioxide under the catalysis of cuprous halide. According to the method, carbon dioxide is used as a C1 source, the cuprous halide is adopted for catalysis, and alkoxide serves as alkali to react in an organic solvent, so the method is simple and easy to implement, has a wide substrate application range, converts various alkenyl boron compounds such as alkenyl boric acid, alkenyl borate and borate into corresponding alpha, beta-unsaturated carboxylic acid under mild conditions, and has a very high yield. The obtained product alpha, beta-unsaturated carboxylic acid is an important intermediate for preparing fine chemical products suchas perfumes, insecticides and the like.
Preparation method of (E, Z)-2, 4-ethyl decadienoate
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Paragraph 0040; 0041, (2019/05/15)
The invention provides a preparation method of (E, Z)-2, 4-ethyl decadienoate. According to the preparation method, n-hexyl aldehyde is taken as an initial raw material, and three step chemical conversion is adopted to prepare a key intermediate 1-bromo heptene; 1-bromo heptene and ethyl acrylate are subjected to coupling reaction under the catalytic effect of a metal catalyst so as to obtain (E,Z)-2, 4-ethyl decadienoate. According to the preparation method, metal catalytic coupling reaction is adopted to replace a step in the prior art that (E, Z)-2, 4-ethyl decadienoate is prepared throughpreparation of an organic copper lithium reagent, water-free oxygen-free harsh conditions are avoided, operation is simplified, reaction efficiency is increased, generation of waste water and waste salt is reduced greatly, equipment investment is reduced, and the preparation method is convenient for industrialization production.
