187164-02-9

Basic information

• Product Name: (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid
• CAS NO: 187164-02-9
• Molecular Weight: 362.406
• Mol File: 187164-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid(187164-02-9)
• EPA Substance Registry System: (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid(187164-02-9)

Safety Data

• Hazardous Substances Data: 187164-02-9(Hazardous Substances Data)

Upstream product

• 187164-01-8 (6-Cyclopropyl-2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetic acid tert-butyl ester 
• 765-43-5 Cyclopropyl methyl ketone 
• 21666-68-2 1-cyclopropyl-3-(dimethylamino)prop-2-en-1-one 
• 187163-98-0 6-cyclopropyl-3-nitropyridin-2(1H)-one 
• 187164-00-7 (3-Amino-6-cyclopropyl-2-oxo-2H-pyridin-1-yl)-acetic acid tert-butyl ester 
• 187163-99-1 (6-Cyclopropyl-3-nitro-2-oxo-2H-pyridin-1-yl)-acetic acid tert-butyl ester 

Relevant articles and documents

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption

1 (L-374,087) is a potent, selective, efficacious, and orally bioavailable thrombin inhibitor that contains a core 3-amino-2-pyridinone moiety. Replacement of the C6 pyridinone metyl group of 1 by a propyl group gave 5 (L-375,052), which retained all the excellent properties of 1, and also yielded higher plasma levels after oral dosing in dogs and rats.