187173-05-3

Basic information

• Product Name: 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE
• Synonyms: BU 224 HYDROCHLORIDE;2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE
• CAS NO: 187173-05-3
• Molecular Formula: C12H12ClN3
• Molecular Weight: 233.7
• Mol File: 187173-05-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.9°Cat760mmHg
• Flash Point: 179.3°C
• Appearance: white/solid
• Density: g/cm³
• Vapor Pressure: 9.33E-06mmHg at 25°C
• Storage Temp.: Desiccate at RT
• Solubility: ethanol: 1.2 mg/mL
• PKA: 9.87±0.40(Predicted)
• CAS DataBase Reference: 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE(187173-05-3)
• EPA Substance Registry System: 2-(4,5-DIHYDROIMIDAZOL-2-YL)QUINOLINE HYDROCHLORIDE(187173-05-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 187173-05-3(Hazardous Substances Data)

Usage

Uses

BU224 is one of the two most widely studied I2 receptor ligands and have antinociceptive and antidepressant-?like activities in rodents.

Biological Activity

High affinity ligand for the imidazoline I 2 binding site (K i = 2.1 nM). Putative I 2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

InChI:InChI=1/C12H11N3.ClH/c1-2-4-10-9(3-1)5-6-11(15-10)12-13-7-8-14-12;/h1-6H,7-8H2,(H,13,14);1H

Upstream product

• 1436-43-7 quinoline-2-carbonitrile 
• 107-15-3 ethylenediamine 
• 5470-96-2 quinoline 2-carbaldehyde 

Relevant articles and documents

Iridium-catalyzed chemoselective transfer hydrogenation of α, β-unsaturated ketones to saturated ketones in water

A chemoselective iridium-catalyzed transfer hydrogenation of α, β-unsaturated ketones was realized in water. The C[dbnd]C double bonds of 2-benzylidene indanones and analogues were hydrogenated exclusively catalyzed by an iridium complex (0.1 mol%) bearin

Ultrasound promoted synthesis of 2-imidazolines in water: A greener approach toward monoamine oxidase inhibitors

A series of sixteen 2-substituted-2-imidazolines (where the substituent R = Ph, Me-4-Ph; MeO-4-Ph; (MeO)2-3,4-Ph; (MeO)3-3,4,5-Ph; Ph-4-O-C(O)-Ph; Cl-4-Ph; Cl-2-Ph; Cl2-2,4-Ph; NO2-4-Ph; NO2-3-Ph; Naphth-2-yl; Fur-2-yl; Benzofur-2-yl; Pyridin-2-yl; Quinolin-2-yl) has been synthesized from the reaction of the substituted-aldehydes and ethylenediamine by ultrasound irradiation with NBS in an aqueous medium in high yields (80-99%). The 2-imidazoline ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO) was investigated and some of them showed potent and selective MAO inhibitory activity especially for the MAO-B isoform and could become promising candidates for future development.