189195-41-3Relevant articles and documents
Optically Active Helical Lanthanide Complexes: Storable Chiral Lewis Acidic Catalysts for Enantioselective Diels–Alder Reaction of Siloxydienes
Harada, Shinji,Nakashima, Saki,Nishida, Atsushi,Oishi, Wakana,Sekino, Shihori
, (2019)
Lanthanide triflates and a series of hexadentate chiral ligand complexes were synthesized. X-ray-quality crystals were obtained from mixtures of the lanthanide complexes, which were helical in shape. The complexes showed Lewis acidity and catalyzed the enantioselective Diels–Alder reaction of electron-rich siloxydienes. The complexes were stable enough to be stored at ambient temperature on a laboratory bench and retained their Lewis acidity even after a month.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00962; 004145-004146, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
Self-assembled porphyrin-based cage complexes, M11L6 (M = ZnII, CdII), with inner coordination sites in their crystal structure
Iizuka, Fumiya,Nakamura, Takashi,Sato, Hiroyasu,Shionoya, Mitsuhiko,Ube, Hitoshi
supporting information, p. 323 - 326 (2020/04/10)
Herein we report self-assembled metallo-cage complexes, M11(L1)6 (M = ZnII, CdII), formed from 4-fold-symmetric ZnII-porphyrin-centered tetrakis-meso-(5¤-methyl-2,2¤-bipyridyl) ligands. The structures of these two D3-symmetric cages have been characterized by 1D and 2D NMR, ESI-MS, and XRD analyses. A common structural feature of these complexes is their inner molecular binding site at the axial position of each square-pyramidal ZnII-porphyrin in the crystal structure, which would provide a method to place molecular coordination sites inside or outside the cage complex with the minimum chemical modification.
Dynamic Helicates Self-Assembly from Homo- and Heterotopic Dynamic Covalent Ligand Strands
Santoro, Antonio,Holub, Jan,Fik-Jaskó?ka, Marta A.,Vantomme, Ghislaine,Lehn, Jean-Marie
supporting information, p. 15664 - 15671 (2020/10/21)
The understanding and the application of reversible covalent reactions and coordination chemistry together with the proper design of the molecular frameworks, allow to achieve not only well-defined output architectures but also different grades of complex behavior. In this work, the dynamic nature of the helical systems offers an additional level of complexity by combining self-sorting on two levels: 1) the build-up of the ligand strand constituents from their components through dynamic covalent chemistry; 2) the assembly of the helicates from the ligands and the metal cations through dynamic metallo-supramolecular chemistry. The information encoded in the ligands constituent molecule was read differently (and accurately at the same time) by metal cations that varied in the coordination algorithms. It enabled the selective formation of a specific type of helicates from a wide library of helicates formed by the possible combination of subcomponents. Ligands containing dynamic tridentate and/or bidentate binding motifs in the same strand were studied to explore the helicates self-assembly with appropriate metal cations.
MACROCYCLIC AZOLOPYRIDINE DERIVATIVES AS EED AND PRC2 MODULATORS
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Paragraph 1078, (2020/10/09)
The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.
Thermodynamic Programming of Erbium(III) Coordination Complexes for Dual Visible/Near-Infrared Luminescence
Golesorkhi, Bahman,Guénée, Laure,Nozary, Homayoun,Fürstenberg, Alexandre,Suffren, Yan,Eliseeva, Svetlana V.,Petoud, Stéphane,Hauser, Andreas,Piguet, Claude
supporting information, p. 13158 - 13169 (2018/09/11)
Intrigued by the unexpected room-temperature dual visible/near-infrared (NIR) luminescence observed for fast-relaxing erbium complexes embedded in triple-stranded helicates, in this contribution, we explore a series of six tridentate N-donor receptors L4–L9 with variable aromaticities and alkyl substituents to extricate the stereoelectronic features responsible for such scarce optical signatures. Detailed solid-state (X-ray diffraction, differential scanning calorimetry, optical spectroscopy) and solution (speciations and thermodynamic stabilities, spectrophotometry, NMR and optical spectroscopy) studies of mononuclear unsaturated [Er(Lk)2]3+ and saturated triple-helical [Er(Lk)3]3+ model complexes reveal that the stereoelectronic changes induced by the organic ligands affect inter- and intramolecular interactions to such an extent that 1) melting temperatures in solids, 2) the affinity for trivalent erbium in solution, and 3) optical properties in luminescent complexes can be rationally varied and controlled. With this toolkit in hand, mononuclear erbium complexes with low stabilities displaying only NIR emission can be transformed into molecular-based dual Er-centered visible/NIR emitters operating at room temperature in both solid and solution states.
Unprecedented One-Pot Reaction towards Chiral, Non-Racemic Copper(I) Complexes of [2.2]Paracyclophane-Based P,N-Ligands
Braun, Carolin,Nieger, Martin,Br?se, Stefan
supporting information, p. 16452 - 16455 (2017/11/27)
Herein, we report a simple one-pot route to enantiopure copper(I) complexes featuring a unique [2.2]paracyclophane-based P,N-ligand system. Phosphine and pyridine moieties can be varied allowing the modular synthesis of these rigid and stable [2.2]paracyclophane-based P,N-ligands. These P,N-ligands are a new ligand class for different transition-metal complexes, which is shown exemplarily for palladium(II).
Catalytic hydrosilylation of alkenes by iron complexes containing terpyridine derivatives as ancillary ligands
Kamata, Kouji,Suzuki, Atsuko,Nakai, Yuta,Nakazawa, Hiroshi
, p. 3825 - 3828 (2012/07/02)
Iron complexes formulated as Fe(terpy)X2 (terpy = 2,2′:6′,2 -terpyridine derivatives; X = Cl, Br) were prepared and their catalytic activities for hydrosilylation of olefin with hydrosilane were examined. Although Fe(terpy)X2 did not
Compounds and Uses Thereof - 848
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Page/Page column 73-74, (2009/01/24)
This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, Rsu
Synthesis of a novel ditopic ligand incorporating directly bonded 1,10-phenanthroline and 2,2′:6′,2″-terpyridine units
Gavi?a, Pablo,Tatay, Sergio
, p. 3471 - 3473 (2007/10/03)
The synthesis of a rigid ditopic ligand incorporating a 1,10-phenanthroline directly connected through its 3-position to the 5-position of a 2,2′:6′,2″-terpyridine is described. The synthesis is based on a series of palladium(0)-catalyzed cross-coupling reactions (Stille and Suzuki couplings) starting from 1,10-phenanthroline and bromo-substituted pyridines.
