189209-27-6

Basic information

• Product Name: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol
• Synonyms: t-boc-N-amido-PEG6-Amine;t-boc-N-amido-PEG5-Amine;t-boc-N-amido-PEG5-Azide;tert-Butyl (17-amino-3,6,9,12,15-pentaoxaheptadecyl)carbamate;Boc-N-amido-PEG5-Amine;Boc-N-amido-PEG5-Azide;O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol;19-AMino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-DiMethylethyl Ester
• CAS NO: 189209-27-6
• Molecular Formula: C₁₇H₃₆N₂O₇
• Molecular Weight: 380.47694
• Product Categories: Aliphatics;Amines;Intermediates;Polyethyleneglycol Derivatives;PEGylation Reagents
• Mol File: 189209-27-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Soluble in Water, DMSO, DCM, DMF
• CAS DataBase Reference: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol(CAS DataBase Reference)
• NIST Chemistry Reference: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol(189209-27-6)
• EPA Substance Registry System: O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol(189209-27-6)

Safety Data

• Hazardous Substances Data: 189209-27-6(Hazardous Substances Data)

Usage

Description

t-Boc-N-Amido-PEG5-amine is a Boc protected PEG linker containing an free amino group and5 PEG units. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters. The Boc group can be deprotected under mild acidic conditions to free the amine.

Uses

As a polyethyleneglycol (PEG) derivative, O-(2-AMinoethyl)-O'-[2-(Boc-aMino)ethyl]tetraethylene Glycol can be used in the preparation of novel biochip technology for detection of explosives-TNT. It is also used as a reagent in the synthesis of chemical inducer of dimeriza tions (CID) to identify the protein target of inhibitors of Toxoplasma gondii invasion.

Upstream product

• 516493-93-9 α-amino,ω-azido,α,ω-dideoxy-hexaethyleneglycol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 72236-26-1 2-(2-(2-(2-(2-(2-aminoethoxy)-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethyl amine 
• 356046-26-9 1-azido-2-[2-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethane 
• 42749-27-9 hexa(ethyleneglycol) ditosylate 
• 1264015-76-0 2-{2-[2-(2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy)ethoxy]ethoxy}ethyl p-tosylate 
• 39160-70-8 3,6,9,12,15,18-hexaoxa-1-octadecyl amine 
• 86770-69-6 17-azido-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 42749-28-0 toluene-4-sulfonic acid 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethyl ester 
• 2615-15-8 pentaethylene glycol 
• 139115-92-7 tert-butyl 2-(2-(2-hydroxyethoxy)ethoxy)ethylcarbamate 
• 86520-52-7 2-[2-(2-azidoethoxy)ethoxy]ethanol 
• 5197-62-6 2-[2-(chloroethoxy)ethoxy]ethanol 
• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 

Downstream Products

• 1355027-79-0 tert-butyl [2-(2,2-dimethyl-4,24-dioxo-3,8,11,14,17,20-hexaoxa-5,23-diazahexacosan-26-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetate 
• 1355027-66-5 [2-(21-amino-3-oxo-7,10,13,16,19-pentaoxa-4-azahenicos-1-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetic acid trifluoroacetate 

Relevant articles and documents

COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION

The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.

EXENATIDE MODIFIER AND USE THEREOF

Disclosed are an exenatide modifier for connecting the exenatide to a fatty chain with a carboxy in the terminus thereof by means of a hydrophilic connecting arm, and a use thereof in preparing drugs serving as a GLP-1 receptor agonist; a use in preparing drugs for preventing and/or treating diseases and/or symptoms associated with a low GLP-1 receptor activity; a use in preparing drugs for diseases and/or symptoms associated with glycometabolism; a use in preparing drugs for diabetes; a use in preparing drugs for fatty liver disease, and a use in preparing drugs for losing weight.

LDV peptidomimetics equipped with biotinylated spacer-arms: Synthesis and biological evaluation on CCRF-CEM cell line

The tripeptide Leu-Asp-Val (LDV) is known to bind α4β 1 integrin in leukemia cells. Here we have synthesized a LDV peptidomimetic equipped with a biotin-conjugated spacer-arm. Compound 9 acts as an inhibitor of the α4β1 integrin in an adhesion assay using fluorescently labeled, α4β 1 integrin-expressing leukemia CCRF-CEM cells. Furthermore, when bound to neutravidin-coated plates, compound 9 could capture CCRF-CEM cells. Such biotin-conjugated LDV peptidomimetic may thus represent a novel tool for biotechnological applications using avidin interaction for leukapheresis or leukemia cell targeting.