18968-05-3

Basic information

• Product Name: 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE
• Synonyms: 1,3,4,6-Tetraacetate β-D-Mannopyranose;1,3,4,6-O-Tetraacetyl-β-D-Mannopyranose;[(2R,3R,4R,5S,6S)-3,4,6-triacetyloxy-5-hydroxyoxan-2-yl]methyl acetate;(2S,3S,4R,5R,6R)-6-(Acetoxymethyl)-3-hydroxytetrahydro-2H-pyran-2,4,5-triyl triacetate;1,3,4,6-Tetra-O-acetyl-β1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE;1,2,3,4-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE;1,3,4,6-Tetra-O-acetyl-?D-mannopyranose
• CAS NO: 18968-05-3
• Molecular Formula: C₁₄H₂₀O₁₀
• Molecular Weight: 348.3
• Product Categories: Intermediates & Fine Chemicals;Labeling and Diagnostics Reagents;Pharmaceuticals;chiral;Biochemistry;O-Substituted Sugars;Sugars;Carbohydrates & Derivatives
• Mol File: 18968-05-3.mol

Chemical Properties

• Melting Point: 160-161 °C(lit.)
• Boiling Point: 425.537 °C at 760 mmHg
• Flash Point: 148.725 °C
• Appearance: /
• Density: 1.339 g/cm³
• Vapor Pressure: 0.329mmHg at 25°C
• Refractive Index: -22.5 ° (C=1.4, CHCl3)
• Storage Temp.: Refrigerator
• Solubility: very faint turbidity in Chloroform
• PKA: 12.22±0.70(Predicted)
• BRN: 96634
• CAS DataBase Reference: 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE(18968-05-3)
• EPA Substance Registry System: 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE(18968-05-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 18968-05-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE is used as an intermediate in the preparation of precursors for the synthesis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG), a radiotracer used in positron emission tomography (PET) for diagnostic purposes. FDG is commonly utilized in detecting cancerous cells, as they exhibit a higher rate of glucose metabolism compared to normal cells. The use of 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE in the synthesis of FDG precursors ensures the production of a reliable and efficient diagnostic tool for various medical applications.
Additionally, due to its unique structure and reactivity, 1,3,4,6-TETRA-O-ACETYL-BETA-D-MANNOPYRANOSE may also be employed as a building block in the development of other pharmaceutical compounds, particularly those targeting carbohydrate-based drug discovery. Its ability to form stable glycosidic linkages with various biomolecules makes it a promising candidate for the synthesis of glycoconjugates, which have potential applications in the treatment of various diseases, including cancer, infectious diseases, and inflammatory conditions.

InChI:InChI=1/C9H15F7O4Si/c1-17-21(18-2,19-3)6-4-5-20-7(10,8(11,12)13)9(14,15)16/h4-6H2,1-3H3

Upstream product

• 3254-16-8 3,4,6-tri-O-acetyl-1,2-O-(1-methoxyethylidene)-β-D-mannopyranose 
• 13242-53-0 acetobromomannose 
• 108-24-7 acetic anhydride 
• 192753-82-5 2-O-benzyl-3,4,5,6-di-O-isopropyliclenealdehydo-L-gulose 
• 530-26-7 D-Mannose 
• 28140-37-6 3,4,6-tri-O-acetyl-1,2-O-[1-(exo-ethoxy)ethylidene]-β-D-mannopyranose 
• 6087-47-4 O³,O⁴,O⁶-triacetyl-O²-trichloroacetyl-β-D-mannopyranosyl chloride 
• 83-87-4 β-D-mannopyranose pentaacetate 
• 13036-15-2 1,3,4,6-tetra-O-acetyl-β-D-glucopyranose 
• 3366-47-0 2,3,4,6-tetra-O-acetyl-1,5-anhydro-D-arabinohex-1-enopyranose 
• 83-87-4 D-Mannose pentaacetate 
• 60-29-7 diethyl ether 
• 28140-37-6 3,4,6-tri-O-acetyl-1,2-O-(1-ethoxyethylidene)-β-D-mannopyranoside 
• 73322-37-9 1,3,4,6-Tetra-O-acetyl-β-D-arabino-hexopyranos-2-ulose monohydrate 

Downstream Products

• 188397-29-7 1,3,4,6-tetra-O-acetyl-2-O-(2,3,4-tri-O-benzoyl-6-O-chloroacetyl-α-D-mannopyranosyl)-β-D-mannopyranose 
• 482576-72-7 N-(9-fluorenylmethoxycarbonyl)-O-[O-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyl)-(1->2)-O-(3,4,6-tri-O-acetyl-α-D-mannopyranosyl)-(1->2)-(3,4,6-tri-O-acetyl-α-D-mannopyranosyl)]-L-threonine benzyl ester 
• 158213-24-2 2-S-β-D-glucopyranosyl-2-thio-β-D-glucopyranose 
• 57884-82-9 2,3,4,6-tetra-O-acetyl-β-D-mannopyranose 

Relevant articles and documents

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