19013-15-1

Basic information

• Product Name: Benzoic acid, 4-Methyl-3-nitro-, ethyl ester
• Synonyms: Benzoic acid, 4-Methyl-3-nitro-, ethyl ester;4-Methyl-3-nitrobenzoic acid ethyl ester
• CAS NO: 19013-15-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• Mol File: 19013-15-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 312.38°C at 760 mmHg
• Flash Point: 137.438°C
• Appearance: /
• Density: 1.217g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: Benzoic acid, 4-Methyl-3-nitro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-Methyl-3-nitro-, ethyl ester(19013-15-1)
• EPA Substance Registry System: Benzoic acid, 4-Methyl-3-nitro-, ethyl ester(19013-15-1)

Safety Data

• Hazardous Substances Data: 19013-15-1(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 4-methyl-3-nitro-, ethyl ester is a chemical compound with the molecular formula C10H11NO4. It is a yellow solid with a fruity odor, and it is commonly used in the production of perfumes and flavorings. Benzoic acid, 4-methyl-3-nitro-, ethyl ester is often synthesized by esterification of benzoic acid with ethanol in the presence of sulfuric acid. It is also used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. Additionally, it has antimicrobial properties and is used as a preservative in food and beverages. However, it is important to note that this compound should be handled with care, as it may cause skin and eye irritation.

InChI:InChI=1/C10H11NO4/c1-3-15-10(12)8-5-4-7(2)9(6-8)11(13)14/h4-6H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 31680-07-6 4-methyl-3-nitrobenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 94-08-6 4-methylbenzoic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 

Downstream Products

• 10397-30-5 4-methyl-3-nitrobenzoyl chloride 
• 641569-94-0 4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid 
• 641569-97-3 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester 
• 641569-96-2 3-guanidino-4-methylbenzoic acid ethyl ester nitrate 
• 1311369-59-1 2-{[(1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-8-yl)carbonyl]amino}benzoic acid 
• 1311369-58-0 methyl 2-{[(1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-8-yl)carbonyl]amino}benzoate 
• 1311369-80-8 1-oxo-N-[3-(1-trityl-1H-imidazol-4-yl)phenyl]-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-63-4 N-[2-(methylcarbamoyl)phenyl]-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-60-1 N-[3-(1H-imidazol-4-yl)phenyl]-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-49-6 N-(2-carbamoylphenyl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311368-46-3 N-(5-benzyl-1,2-oxazol-3-yl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311366-35-4 N-(3-chlorophenyl)-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide 
• 1311369-17-1 diethyl 1-(2,2-difluoro-3-{[(4-methylphenyl)sulfonyl]oxy}propyl)-1H-indole-2,6-dicarboxylate 
• 107516-75-6 diethyl 1H-indole-2,6-dicarboxylate 

Relevant articles and documents

Method for preparing N-(5-carboxyl-2-methylphenyl)-4-(3-pyridine)-2-pyrilamine

The invention discloses a method for preparing N-(5-carboxyl-2-methylphenyl)-4-(3-pyridine)-2-pyrilamine. The method specifically comprises the following steps: step 1, carrying out ethyl esterification reaction on 3-nitro-4-methyl benzoic acid serving as an initial raw material to generate a compound 2; step 2, reducing nitro of the compound 2 through hydrogenation reduction reaction in the presence of palladium on carbon to generate a compound 3; step 3, reacting the compound 3 with a nitrile amine aqueous solution, and then carrying out base exchange to obtain a compound 4; step 4, carrying out cyclization between the compound 4 and a compound 6 to obtain a compound 7; and step 5, hydrolyzing the compound 7 under the action of an alkaline to generate a compound 8, namely N-(5-carboxyl-2-methylphenyl)-4-(3-pyridine)-2-pyrilamine. The method overcomes the defects that in the prior art such as long reaction time, low yield, high cost, difficulty for industrial production, and the like. A preparation method, which is high in yield, is environmentally-friendly, and is suitable for industrial production, is provided.

MK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties

We describe the discovery of novel potent substituted pyrimido[4,5-c] quinoline ATP-competitive inhibitors of protein kinase CK2. A binding model of the inhibitors with the protein was elaborated on the basis of SAR and revealed various modes of interacti