19063-54-8

Basic information

• Product Name: 7-Chloro-2H-chromen-2-one
• Synonyms: 7-Chloro-2H-chromen-2-one
• CAS NO: 19063-54-8
• Molecular Weight: 180.59
• Mol File: 19063-54-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 7-Chloro-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-2H-chromen-2-one(19063-54-8)
• EPA Substance Registry System: 7-Chloro-2H-chromen-2-one(19063-54-8)

Safety Data

• Hazardous Substances Data: 19063-54-8(Hazardous Substances Data)

Upstream product

• 2420-26-0 4-chlorosalicylaldehyde 
• 108-24-7 acetic anhydride 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
• 1615-02-7 p-chlorocinnamic acid 
• 108-43-0 3-monochlorophenol 
• 471-25-0 Propiolic acid 
• 292638-85-8 acrylic acid methyl ester 
• 53581-86-5 4-chloro-2-methoxybenzaldehyde 
• 617-48-1 malic acid 
• 105786-77-4 3-Ethoxyacrylsaeure-3-chlorphenylester 

Relevant articles and documents

Visible-light promoted oxidative cyclization of cinnamic acid derivatives using xanthone as the photocatalyst

We have developed an efficient photocatalytic synthesis of coumarin derivativesviaa tandem double bond isomerization/oxidative cyclization of cinnamic acids. Inexpensive and stable xanthone was used as the photocatalyst, and readily available Selectfluor was used as the oxidant. This method tolerates a wide range of functional groups and offers excellent chemical yields in general. Besides, the photocatalytic oxidative cyclization of cinnamic acid esters gives dimerized lignan-type products.

Visible-Light-Induced Direct Csp2-H Radical Trifluoroethylation of Coumarins with 1,1,1-Trifluoro-2-iodoethane (CF3CH2I)

Herein, we developed the first visible-light-induced direct Csp2-H radical 2,2,2-trifluoroethylation of coumarins with commercially available and cheap reagent CF3CH2I at room temperature. This transformation proceeded smoothly under mild conditions and showed excellent functional group compatibility. The synthetic value of the protocol was also demonstrated by the successful functionalization of several pharmaceuticals.

Visible-light-induced regioselective alkylation of coumarins via decarboxylative coupling with N-hydroxyphthalimide esters

An efficient photocatalytic decarboxylative 3-position alkylation of coumarins by using alkyl N-hydroxyphthalimide esters as alkylation reagents has been developed. A variety of NHP esters derived from aliphatic carboxylic acids (primary, secondary, and tertiary) has been proved to be tolerated for this decarboxylation process, affording a broad scope of 3-alkylated coumarin derivatives in moderate to excellent yields. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.