191152-27-9

Basic information

• Product Name: D-erythro-Pentonic acid, 2,3-dideoxy-2-(1-methylethyl)-, gamma-lactone (9CI)
• Synonyms: D-erythro-Pentonic acid, 2,3-dideoxy-2-(1-methylethyl)-, gamma-lactone (9CI)
• CAS NO: 191152-27-9
• Molecular Formula: C8H14O3
• Molecular Weight: 158.19496
• Product Categories: ISOPROPYL
• Mol File: 191152-27-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-erythro-Pentonic acid, 2,3-dideoxy-2-(1-methylethyl)-, gamma-lactone (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: D-erythro-Pentonic acid, 2,3-dideoxy-2-(1-methylethyl)-, gamma-lactone (9CI)(191152-27-9)
• EPA Substance Registry System: D-erythro-Pentonic acid, 2,3-dideoxy-2-(1-methylethyl)-, gamma-lactone (9CI)(191152-27-9)

Safety Data

• Hazardous Substances Data: 191152-27-9(Hazardous Substances Data)

Upstream product

• 191152-31-5 (3S,5S)-5-[[tert-butyl(diphenyl)silyl]oxymethyl]-3-(1-hydroxy-1-methyl-ethyl)tetrahydrofuran-2-one 
• 191152-34-8 (3S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-isopropyl-dihydro-furan-2-one 
• 191152-29-1 (R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-isopropylidene-dihydro-furan-2-one 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 
• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 
• 324763-41-9 (2S,3S,5R,7S,9S)-7-Bromomethyl-9-isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]nonane 
• 324763-40-8 (S)-2-Isopropyl-pent-4-enoic acid ((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide 
• 192060-34-7 N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-N-dimethylbutyramide 
• 324763-42-0 ((2S,3S,5R,7S,9S)-9-Isopropyl-3,4-dimethyl-2-phenyl-1,6-dioxa-4-aza-spiro[4.4]non-7-yl)-methanol 
• 191152-26-8 (3S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-isopropyl-dihydro-furan-2-one 
• 191152-32-6 Oxalic acid 1-[(3S,5S)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-tetrahydro-furan-3-yl]-1-methyl-ethyl ester methyl ester 

Downstream Products

• 325740-60-1 tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride 
• 325740-64-5 (3S,5S)-3-Isopropyl-5-{(S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one 
• 324763-45-3 (3S,5S)-5-{(1R,3S)-1-Hydroxy-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one 
• 325740-67-8 (3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one 
• 325740-70-3 (3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 324763-46-4 (3S,5S)-5-{(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one 
• 325740-68-9 Methanesulfonic acid (1R,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester 
• 325740-69-0 Methanesulfonic acid (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester 
• 325740-72-5 (3S,5S)-5-{(S)-1-[(Z)-Benzyloxyimino]-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl}-3-isopropyl-dihydro-furan-2-one 
• 325154-32-3 (2S,4S,5R,7S)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl-2-isopropylnonanamide 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 325154-31-2 (2S,4S,5R,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 325740-59-8 tetrahydro-4-isopropyl-5-oxofuran-2-carboxylic acid 

Relevant articles and documents

A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate

We report a convergent synthesis of the potent orally active non-peptide renin inhibitor CGP60536B. The key reaction employs the coupling of the enantiopure Grignard species derived from chloride 13 with the diastereomerically pure γlactone 9b. The stereoselective reduction of the resulting ketone 14b has been thoroughly investigated. (C) 2000 Elsevier Science Ltd.

Synthesis of (4S)-hydroxymethyl-(2R)-(2-propyl)-butyrolactone: A quest for a practical route to an important hydroxyethylene isostere chiron

Several approaches for the stereocontrolled introduction of a 2-propyl group into (4S)-hydroxymethyl-1,4-butyrolactone via cholate chemistry were investigated. A practical synthesis of the (2R)- and (2S)-isomers was developed.