19352-29-5

Basic information

• Product Name: 3-PHENYL-4-PICOLINE
• Synonyms: 4-METHYL-3-PHENYLPYRIDINE;3-PHENYL-4-PICOLINE
• CAS NO: 19352-29-5
• Molecular Formula: C₁₂H₁₁N
• Molecular Weight: 169.22
• Mol File: 19352-29-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 281.9 °C at 760 mmHg
• Flash Point: 117.6 °C
• Appearance: /
• Density: 1.03 g/cm³
• Vapor Pressure: 0.0059mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-PHENYL-4-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENYL-4-PICOLINE(19352-29-5)
• EPA Substance Registry System: 3-PHENYL-4-PICOLINE(19352-29-5)

Safety Data

• Hazardous Substances Data: 19352-29-5(Hazardous Substances Data)

Usage

General Description

3-Phenyl-4-picoline, also known as 2-(3-Methylpyridin-4-yl)benzene, is a chemical compound with the molecular formula C13H12N2. This chemical is utilized in the field of organic synthesis, where it forms a significant component in a variety of chemical reactions. The structure of 3-phenyl-4-picoline is characterized by a benzene ring bonded to a pyridine ring, which contributes to its unique chemical properties. Considered hazardous, this compound can pose possible risks on skin contact, inhalation, or if swallowed, therefore appropriate safety measures must be taken in handling it. Its exact physical properties such as melting point, boiling point, or density may vary based on the source and these are crucial in identifying purity and quality of the compound.

InChI:InChI=1/C12H11N/c1-10-7-8-13-9-12(10)11-5-3-2-4-6-11/h2-9H,1H3

Upstream product

• 72093-04-0 3-chloro-4-methylpyridine 
• 100-58-3 phenylmagnesium bromide 
• 108-89-4 picoline 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 3430-27-1 3-amino-4-methylpyridine 
• 591-50-4 iodobenzene 
• 73183-34-3 bis(pinacol)diborane 
• 1379538-78-9 (E)-N-(but-2-en-1-yl)-N-tert-butoxycarbonyl-phenylethynylamine 
• 3430-22-6 3-Bromo-4-methylpyridin 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 1171891-31-8 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 60-12-8 2-phenylethanol 
• 123-73-9 crotonaldehyde 

Downstream Products

• 60750-02-9 2-(p-biphenylyl)-4-methyl-5-phenylpyridine 
• 60750-01-8 2-(p-biphenylyl)-4-methyl-3-phenylpyridine 
• 135-70-6 p-quaterphenyl 
• 244-42-8 3-azafluorene 
• 18631-22-6 5H-indeno[1,2-c]pyridin-5-one 
• 104096-15-3 3-phenylpyridine-4-carboxylic acid 

Relevant articles and documents

Four-Selective Pyridine Alkylation via Wittig Olefination of Dearomatized Pyridylphosphonium Ylides

Methods to synthesize alkylated pyridines are valuable because these structures are prevalent in pharmaceuticals and agrochemicals. We have developed a distinct approach to construct 4-alkylpyridines using dearomatized pyridylphosphonium ylide intermediates in a Wittig olefination-rearomatization sequence. Pyridine N-activation is key to this strategy, and N-triazinylpyridinium salts enable coupling between a wide variety of substituted pyridines and aldehydes. The alkylation protocol is viable for late-stage functionalization, including methylation of pyridine-containing drugs. This approach represents an alternative to metal-catalyzed sp2-sp3 cross-coupling reactions and Minisci-type processes.

NON-PEPTIDE OPIOID RECEPTOR MODULATORS

Non-peptide MOR opioid receptor modulators are provided. The compounds exhibit predominantly central activity and are used to treat e.g. opioid addiction. The compounds described herein are generally delivered (administered) in a pharmaceutical compositio

Scope of regioselective Suzuki reactions in the synthesis of arylpyridines and benzylpyridines and subsequent intramolecular cyclizations to azafluorenes and azafluorenones

The current investigation on regioselective Suzuki reactions of 2,3-dihalopyridines and 2-halo-3-halomethylpyridines yielded the unexplored synthesis of arylpyridines and benzylpyridines bearing synthetic handles for further functionalization. Indeed, the scope of intramolecular cyclizations of arylpyridines and benzylpyridines prepared in this study for the synthesis of azafluorenes and azafluorenones has been investigated.