193959-26-1Relevant articles and documents
Efficient and highly stereoselective synthesis of a β-lactam inhibitor of the serine protease prostate-specific antigen
Annunziata, Rita,Benaglia, Maurizio,Cinquini, Mauro,Cozzi, Franco,Puglisi, Alessandra
, p. 1813 - 1818 (2007/10/03)
An efficient synthesis of a β-lactam precursor of the serine protease, prostate-specific antigen inhibitor 1 has been accomplished. The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 an
Design and synthesis of novel monocyclic β-lactam inhibitors of prostate specific antigen
Adlington, Robert M.,Baldwin, Jack E.,Chen, Beining,Cooper, Stephen L.,McCoull, William,Pritchard, Gareth J.,Howe, Trevor J.,Becker, Gerald W.,Hermann, Robert B.,McNulty, Ann M.,Neubauer, Blake L.
, p. 1689 - 1694 (2007/10/03)
A novel series of monocyclic β-lactam analogues was designed using a homology derived model of prostate specific antigen (PSA) and by application of a multiple copy simultaneous search technique. Syntheses were conducted by assembly of the β-lactam core v