195609-18-8

Basic information

• Product Name: 2-FLUORO-5-NITROPHENYLACETIC ACID
• Synonyms: 2-FLUORO-5-NITROPHENYLACETIC ACID;2-(2-Fluoro-5-nitrophenyl)acetic acid;3-(Carboxymethyl)-4-fluoronitrobenzene;2-fluoro-5-nitrophenyl acetate
• CAS NO: 195609-18-8
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.14
• EINECS: 242-641-0
• Product Categories: Phenylacetic acid
• Mol File: 195609-18-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 149-150
• Boiling Point: 375.5°C at 760 mmHg
• Flash Point: 180.9°C
• Appearance: /
• Density: 1.498
• Vapor Pressure: 2.63E-06mmHg at 25°C
• Refractive Index: 1.574
• PKA: 3.76±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-5-NITROPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-5-NITROPHENYLACETIC ACID(195609-18-8)
• EPA Substance Registry System: 2-FLUORO-5-NITROPHENYLACETIC ACID(195609-18-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 195609-18-8(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline

InChI:InChI=1/C8H6FNO4/c9-7-2-1-6(10(13)14)3-5(7)4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 1000339-92-3 2-(2-fluoro-5-nitrophenyl)acetonitrile 
• 451-82-1 (2-fluorophenyl)acetic acid 

Downstream Products

• 1021389-31-0 2-(2-fluoro-5-nitrophenyl)ethanol 
• 1403480-41-0 N-((2R,3R)-3-(allyloxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-2-(2-fluoro-5-nitrophenyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)acetamide 

Relevant articles and documents

New strategy for detection of hydrogen peroxide based on bi-nucleophilic reaction

Two novel fluorescent probes based on 7-hydroxy-4-methyl-coumarin, FAA-MC-OH (2-fluoro-4-nitro-phenylacetyl hydroxyl coumarin) and FBA-MC-OH (2-fluoro-4-nitro-benzoyl hydroxyl coumarin) are first synthesized, and spectral studies confirm that both the pro

RAF INHIBITOR COMPOUNDS

This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.

Benzo-fused heterocycles and carbocycles by intramolecular SNAr and tandem SN2-SNAr reactions

(Chemical Equation Presented) Benzo-fused heterocyclic and carbocyclic systems have been synthesized by intramolecular SNAr and tandem SN2-SNAr reactions. Treatment of 3-(2-fluoro-5- nitrophenyl)-1-propanol with sodium hydride in N,N-dimethylformamide gave 6-nitrochroman in 80% yield by an intramolecular SNAr reaction. Treatment of 2-(3-bromopropyl)-1-fluoro-4-nitrobenzene with benzylamine in N,N-dimethylformamide gave 1-benzyl-6-nitrotetrahydroquinoline in 98% yield by a tandem SN2-SNAr reaction. Finally, in a similar process, reaction of this same bromide with dimethyl malonate under basic conditions gave 1,1-bis(methoxycarbonyl)-6-nitro-1,2,3,4-tetrahydronaphthalene in 80% yield. Further studies exploring ring size effects are also presented.