19614-15-4

Basic information

• Product Name: ETHYL 4-MORPHOLINOBENZENECARBOXYLATE
• Synonyms: ETHYL 4-MORPHOLINOBENZENECARBOXYLATE;RARECHEM AL BI 1130;Ethyl 4-(morpholin-4-yl)benzoate;Ethyl 4-Morpholinobenzoate;Benzoic acid,4-(4-morpholinyl)-, ethyl ester
• CAS NO: 19614-15-4
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.28
• Product Categories: pharmacetical
• Mol File: 19614-15-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 86-88°
• Boiling Point: 383.8°Cat760mmHg
• Flash Point: 185.9°C
• Appearance: /
• Density: 1.135g/cm³
• Vapor Pressure: 4.29E-06mmHg at 25°C
• Refractive Index: 1.534
• PKA: 2?+-.0.40(Predicted)
• CAS DataBase Reference: ETHYL 4-MORPHOLINOBENZENECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-MORPHOLINOBENZENECARBOXYLATE(19614-15-4)
• EPA Substance Registry System: ETHYL 4-MORPHOLINOBENZENECARBOXYLATE(19614-15-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 19614-15-4(Hazardous Substances Data)

Usage

General Description

ETHYL 4-MORPHOLINOBENZENECARBOXYLATE is a chemical compound with a molecular formula C13H17NO3. It is a white to off-white crystalline powder that is used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical products. The compound has a morpholine ring and a carboxylic acid group, and it is commonly used as a building block in the production of various drugs. It is also used as a reagent in organic synthesis and as a precursor in the production of agricultural chemicals.ETHYL 4-MORPHOLINOBENZENECARBOXYLATE has a wide range of applications and is an important compound in the field of organic chemistry.

InChI:InChI=1/C13H17NO3/c1-2-17-13(15)11-3-5-12(6-4-11)14-7-9-16-10-8-14/h3-6H,2,7-10H2,1H3

Upstream product

• 110-91-8 morpholine 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 34604-52-9 diethylene glycol dimesylate 
• 94-09-7 p-aminoethylbenzoate 
• 1312161-41-3 C₂₇H₂₇O₁₀P 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 111-44-4 3-oxa-1,5-dichloropentane 

Downstream Products

• 7470-38-4 4-morpholin-4-yl-benzoic acid 
• 183557-77-9 (4-morpholin-4-yl-phenyl)-amide 
• 720720-60-5 4-(3-oxomorpholin-4-yl)benzoic acid 
• 766556-56-3 ethyl 4-(3-oxomorpholino)benzoate 
• 19620-58-7 bis-(2-methylsulfanylmethyl-phenyl)-(4-morpholin-4-yl-phenyl)-methanol 

Relevant articles and documents

Electrochemical Cross-Dehydrogenative Aromatization Protocol for the Synthesis of Aromatic Amines

The introduction of amines onto aromatics without metal catalysts and chemical oxidants is synthetically challenging. Herein, we report the first example of an electrochemical cross-dehydrogenative aromatization (ECDA) reaction of saturated cyclohexanones and amines to construct anilines without additional metal catalysts and chemical oxidants. This reaction exhibits a broad scope of cyclohexanones including heterocyclic ketones, affording a variety of aromatic amines with various functionalities, and shows great potential in the synthesis of biologically active compounds.

Dihalogen-bridged NHC-palladium(i) dimers: Synthesis, characterisation and applications in cross-coupling reactions

A di-iodo-bridged PdI dimer bearing an N-heterocyclic carbene ligand was made accessible via the reduction of [(IPr)PdI2]2 in basic methanol solution. The structural features of [(IPr)PdI]2 were explored by single-crystal X-ray analysis. It was found to be a convenient one-component precatalyst with high activity in Suzuki-Miyaura, Buchwald-Hartwig, and Sonogashira reactions.

Silver-catalyzed intermolecular amination of fluoroarenes

A novel highly selective Ag-catalyzed intermolecular amination of fluoroarenes has been developed. This transformation starts from readily available 4-carbonyl fluorobenzene and NaN3 or other nitrogen-source, via amination followed by C-F bond cleavage, thus affording the desired 4-carbonyl arylamine products under mild conditions. The reaction is accelerated using a small amount of water. This pathway is distinct from a previously reported radical amination reaction.