Welcome to LookChem.com Sign In|Join Free

Cas Database

1973-09-7

1973-09-7

Identification

  • Product Name:1,3,5-Triazine-2,4-diamine, 6-chloro-N,N-diphenyl-

  • CAS Number: 1973-09-7

  • EINECS:

  • Molecular Weight:297.747

  • Molecular Formula: C15H12ClN5

  • HS Code:2933699090

  • Mol File:1973-09-7.mol

Synonyms:1,3,5-Triazine-2,4-diamine, 6-chloro-N,N‘-diphenyl-;1,3,5-Triazine-2,4-diamine,6-chloro-N,N'-diphenyl;6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Crysdot
  • Product Description:6-Chloro-N2,N4-diphenyl-1,3,5-triazine-2,4-diamine 95+%
  • Packaging:5g
  • Price:$ 495
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:6-CHLORO-N,N'-DIPHENYL-1,3,5-TRIAZINE-2,4-DIAMINE 95.00%
  • Packaging:1G
  • Price:$ 685.21
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 28 Articles be found

Optoelectronic and charge transport properties of D-n-A type 1,3,5-triazine derivatives: A combined experimental and DFT study

Chetti, Prabhakar,Pola, Someshwar,V. M., Vidya

, (2020/10/02)

The synthesis of five D-n-A type star-shaped octupolar molecules is presented in the current work. The exploration of the potential applicability of molecules under study in organic optoelectronics as electron or hole transporting materials is carried out by DFT methods. All the molecules have a 1,3,5-triazine core, which acts as an electron acceptor (A). Phenyl ring and pyridine ring act as electron donors (D) in AZ and PZ series of molecules respectively. The donor and acceptor core are connected by -NH bridge (n). The crystal structure of a molecule in the PZ series is elucidated. Thermogravimetric studies are carried out to confirm the thermal stability of molecules. The frontier molecular orbitals of molecules are characterized with the help of cyclic voltammetry. With the assistance of DFT methodologies, the whole research presented in this work focuses on the electronic excitations, reorganization energies, electron affinity, ionization potential and features of frontier molecular orbitals of molecules. The investigation of the variation of optoelectronic properties of molecules with changing patterns of nucleophilic substitution on 1,3,5-triazine core and presence of a hetero (nitrogen) atom in the donor part of the molecule is also accomplished.

Heterocyclic IDH mutant inhibitor, preparation method and application thereof

-

, (2020/09/23)

The invention discloses a heterocyclic IDH mutant inhibitor, a preparation method and application thereof, belongs to the field of medicines, and particularly relates to a s-triazine compound with structural characteristics of a general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition, a preparation method of the s-triazine compound, and application of the s-triazine compound or the pharmaceutically acceptable salt and the pharmaceutical composition as isocitrate dehydrogenase 2 (IDH2) mutant inhibitors. The compound disclosed by the invention has an obvious inhibiting effect on the activity of an IDH2 mutant (mIDH2), can effectively inhibit the process of catalyzing alpha-ketoglutaric acid to generate 2-hydroxyglutaric acid by the mIDH2, and can be used for preventing and/or treating various related diseases including cancers caused by IDH2 mutation.

Synthesis, Spectra, and Theoretical Investigations of 1,3,5-Triazines Compounds as Ultraviolet Rays Absorber Based on Time-Dependent Density Functional Calculations and three-Dimensional Quantitative Structure-Property Relationship

Wang, Xueding,Xu, Yilian,Yang, Lu,Lu, Xiang,Zou, Hao,Yang, Weiqing,Zhang, Yuanyuan,Li, Zicheng,Ma, Menglin

, p. 707 - 723 (2018/05/05)

A series of 1,3,5-triazines were synthesized and their UV absorption properties were tested. The computational chemistry methods were used to construct quantitative structure-property relationship (QSPR), which was used to computer aided design of new 1,3,5-triazines ultraviolet rays absorber compounds. The experimental UV absorption data are in good agreement with those predicted data using the Time-dependent density functional theory (TD-DFT) [B3LYP/6–311 + G(d,p)]. A suitable forecasting model (R > 0.8, P 0.0001) was revealed. Predictive three-dimensional quantitative structure-property relationship (3D-QSPR) model was established using multifit molecular alignment rule of Sybyl program, which conclusion is consistent with the TD-DFT calculation. The exceptional photostability mechanism of such ultraviolet rays absorber compounds was studied and confirmed as principally banked upon their ability to undergo excited-state deactivation via an ultrafast excited-state proton transfer (ESIPT). The intramolecular hydrogen bond (IMHB) of 1,3,5-triazines compounds is the basis for the excited state proton transfer, which was explored by IR spectroscopy, UV spectra, structural and energetic aspects of different conformers and frontier molecular orbitals analysis.

Dissociation exists in s-triazine based donor-accepter organic systems by photo-induced electron transfer

Wang, Tianyang,Sun, Haiya,Lu, Ting,Li, Fengqing,Liu, Dongzhi,Li, Wei,Zhou, Xueqin,Wang, Lichang,Wang, Tianyang,Sun, Haiya,Lu, Ting,Li, Fengqing,Hu, Wenping,Li, Wei,Zhou, Xueqin,Wang, Lichang,Bridgmohan, Chelsea N.,Wang, Lichang,Liu, Dongzhi,Li, Wei,Zhou, Xueqin,Hu, Wenping

, p. 264 - 273 (2016/12/28)

In the organic donor-acceptor system, the dissociation of the chloride anion in the s-triazine group as the acceptor was first investigated under irradiation. Introducing the electron-deficient chromophore as acceptor 2 to the donor-acceptor module allows the photo-induced electron transfer from the s-triazine module, making the dissociation less in the donor-acceptor1-acceptor2 architecture, which has been proven to be a good strategy to increase light-stability.

Cardioprotective effect of novel sulphonamides-1,3,5-triazine conjugates against ischaemic–reperfusion injury via selective inhibition of MMP-9

Zheng, Xiao-Zhu,Zhou, Jia-Li,Ye, Jing,Guo, Pei-Pei,Lin, Chun-Shui

, p. 756 - 765 (2016/10/19)

Diseases affecting cardiovascular system are ranked as a top most cause of morbidity and mortality. Herein, a novel class sulphonamides-1,3,5-triazine conjugates have been synthesized and tested for inhibitory activity against MMP-2 and MMP-9. The results of the study showed that these molecules efficiently inhibit MMP-9 than MMP-2, revealing compound 8e as the most potent inhibitor (IC50?=?2.34?±?0.56?nm). Due to involvement of MMP-9 in many cardiovascular diseases, particularly in myocardial ischaemia (MI), compound 8e was further subjected for the determination of the protective effect on isoproterenol (ISO)-induced myocardial injury in rats.

Process route upstream and downstream products

Process route

1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
In acetone; at 0 ℃;
98%
1,3,5-trichloro-2,4,6-triazine; In acetone; at 40 ℃; for 0.5h;
aniline; With sodium hydroxide; In water; acetone; at 0 - 40 ℃; for 2h;
98%
With sodium acetate; acetic acid; In water; at 20 ℃; for 4h;
96%
With sodium acetate; In water; acetic acid; at 20 ℃;
96%
In acetone; at 0 - 35 ℃; for 6h;
93%
With sodium carbonate; In acetone; at 0 - 20 ℃;
86%
With potassium carbonate; In toluene; at 20 ℃; for 4h;
70%
With acetic acid; triethylamine; at 35 ℃; for 6h;
66%
In tetrahydrofuran; at 40 ℃; for 1.33333h; Inert atmosphere;
62.2%
With ethanol; water;
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 50 ℃;
With sodium carbonate; In acetone; at 20 ℃;
With sodium carbonate; In acetone; at 0 - 20 ℃;
5.9 g
With sodium hydroxide; at 40 - 45 ℃;
In acetone; at 0 - 45 ℃; for 9h;
2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
In acetone; at 20 ℃; for 6h;
80%
2-phenylamino-4,6-dichloro-s-triazine; aniline; In acetone; at 20 ℃; for 4h;
With sodium carbonate; In acetone;
80%
2-phenylamino-4,6-dichloro-s-triazine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.0333333h;
aniline; In tetrahydrofuran; at 20 ℃; for 6h;
75%
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃;
In tetrahydrofuran; at 20 ℃; for 2h;
With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;
With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;
In acetone; at 20 ℃;
In acetone; at 20 ℃;
In tetrahydrofuran; at 35 - 40 ℃;
In acetone; at 20 ℃;
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

aniline
62-53-3

aniline

2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
With triethylamine; In acetone; at 0 - 20 ℃; for 7h;
53%
10%
aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: acetone / 0 - 5 °C
2: acetone / 20 °C
In acetone;
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 5 °C
2: tetrahydrofuran / 35 - 40 °C
In tetrahydrofuran;
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.03 h / Cooling with ice
1.2: 4.5 h / 20 °C / Cooling with ice
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
2.2: 6 h / 20 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: DIPEA / tetrahydrofuran / 60 °C
2: DIPEA / tetrahydrofuran / 60 °C
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
48%
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
In acetone; at 0 ℃;
98%
1,3,5-trichloro-2,4,6-triazine; In acetone; at 40 ℃; for 0.5h;
aniline; With sodium hydroxide; In water; acetone; at 0 - 40 ℃; for 2h;
98%
With sodium acetate; acetic acid; In water; at 20 ℃; for 4h;
96%
With sodium acetate; In water; acetic acid; at 20 ℃;
96%
In acetone; at 0 - 35 ℃; for 6h;
93%
With sodium carbonate; In acetone; at 0 - 20 ℃;
86%
With potassium carbonate; In toluene; at 20 ℃; for 4h;
70%
With acetic acid; triethylamine; at 35 ℃; for 6h;
66%
In tetrahydrofuran; at 40 ℃; for 1.33333h; Inert atmosphere;
62.2%
With ethanol; water;
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 - 50 ℃;
With sodium carbonate; In acetone; at 20 ℃;
With sodium carbonate; In acetone; at 0 - 20 ℃;
5.9 g
With sodium hydroxide; at 40 - 45 ℃;
In acetone; at 0 - 45 ℃; for 9h;
2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
In acetone; at 20 ℃; for 6h;
80%
2-phenylamino-4,6-dichloro-s-triazine; aniline; In acetone; at 20 ℃; for 4h;
With sodium carbonate; In acetone;
80%
2-phenylamino-4,6-dichloro-s-triazine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.0333333h;
aniline; In tetrahydrofuran; at 20 ℃; for 6h;
75%
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 60 ℃;
In tetrahydrofuran; at 20 ℃; for 2h;
With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 3h;
With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;
In acetone; at 20 ℃;
In acetone; at 20 ℃;
In tetrahydrofuran; at 35 - 40 ℃;
In acetone; at 20 ℃;
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

aniline
62-53-3

aniline

2-phenylamino-4,6-dichloro-s-triazine
2272-40-4

2-phenylamino-4,6-dichloro-s-triazine

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
With triethylamine; In acetone; at 0 - 20 ℃; for 7h;
53%
10%
aniline
62-53-3

aniline

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine
1973-09-7

6-chloro-N,N'-diphenyl-1,3,5-triazine-2,4-diamine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: acetone / 0 - 5 °C
2: acetone / 20 °C
In acetone;
Multi-step reaction with 2 steps
1: tetrahydrofuran / 0 - 5 °C
2: tetrahydrofuran / 35 - 40 °C
In tetrahydrofuran;
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.03 h / Cooling with ice
1.2: 4.5 h / 20 °C / Cooling with ice
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.03 h
2.2: 6 h / 20 °C
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Global suppliers and manufacturers

Global( 4) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1973-09-7
Post Buying Request Now
close
Remarks: The blank with*must be completed