19875-04-8

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI);2-methylpyrimidin-4(3H)-one;2-METHYLPYRIMIDIN-4(3H)-ONE,PURITY:95% MIN(HPLC);2-Methyl-4-pyrimidinol;2-Methylpyrimidin-4(1H)-one;2-Methylpyrimidine-4(3H)-one;2-Methylpyrimidine-4-ol;2-Methyl-4(3H)-pyrimidinone
• CAS NO: 19875-04-8
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Product Categories: PYRIMIDINE
• Mol File: 19875-04-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 214 °C
• Boiling Point: 190.3 °C at 760 mmHg
• Flash Point: 68.9 °C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.545mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.43±0.40(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)(19875-04-8)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI)(19875-04-8)

Safety Data

• Hazardous Substances Data: 19875-04-8(Hazardous Substances Data)

Usage

Uses

4-Hydroxy-2-methylpyrimidine is a useful synthetic intermediate. It is an intermediate used to synthesize 2-Methyl-4-pyrimidinyl-boronic Acid (M328125) which is used to synthesize indazole-derived S-adenosyl homocysteine/methylthioadenosine nucleosidase inhibitors with antimicrobial activities.

InChI:InChI=1/C5H6N2O/c1-4-6-3-2-5(8)7-4/h2-3H,1H3,(H,6,7,8)

Upstream product

• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 124-42-5 acetamidine hydrochloride 
• 5941-55-9 ethyl 3-ethoxyacrylate 
• 106690-58-8 5,8-Methano-2-methyl-r-4a,c-5,c-8,c-8a-tetrahydroquinazolin-4(3H)-one 
• 7314-67-2 4-isopropoxy-2-methyl-pyrimidine 

Downstream Products

• 17758-38-2 2,3-Dimethyl-4(3H)pyrimidone 
• 7314-65-0 4-methoxy-2-methyl-pyrimidine 
• 1676-57-9 5-bromo-2-methyl-4(3H)-pyrimidinone 
• 4994-86-9 4-chloro-2-methylpyrimidine 
• 698-29-3 2-methyl-4-amino-5-cyanopyrimidine 
• 111079-17-5 2-methyl-4-chloro-5-iodopyrimidine 
• 56844-01-0 2-methyl-thieno[2,3-d]pyrimidine 
• 155006-22-7 2-methyl-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4(1H)-pyrimidinone 
• 111079-41-5 5-iodo-2-methyl-4(3H)-pyrimidinone 

Relevant articles and documents

Novel pyrimidine nucleoside oxosulfonium ylides and their photolysis to 2,2'-methylenecyclonucleosides.

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ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)

PIPERAZINE SUBSTITUTED PYRIMIDINE DERIVATIVES AND PHYSIOLOGICALLY TOLERATED SALTS THEREOF

Pyrimidine derivatives of the formula I I in which R1, R2, R3, R4 and R5 have the indicated meanings, the salts thereof, and a process for the preparation thereof are described. Because of their sorbitol-accumulating activity, they are suitable as a tool in a pharmacological screening model for aldose reductase inhibitors