199593-08-3

Basic information

• Product Name: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE
• Synonyms: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE;N4-Acetyl-5'-O-DMT-2'-O-methyl-D-cytidine;DMT-2'-OMe-Ac-C;N4-Acetyl-5'-O-DMT-2'-O-methylcytidine;N-(1-((2R,3R,4R,5R)-5-((bis(4-Methoxyphenyl)(phenyl)Methoxy)Methyl)-4-hydroxy-3-Methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyriMidin-4-yl)acetaMide;N-Acetyl-5'-O-(4,4'-diMethoxytrityl)-2'-O-Methylcytidine;N-Acetyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-cytidine;5'-O-DMT-N4-Acetyl-2'-O-Methyl-cytidine
• CAS NO: 199593-08-3
• Molecular Formula: C₃₃H₃₅N₃O₈
• Molecular Weight: 601.6463
• EINECS: 2017-001-1
• Mol File: 199593-08-3.mol
• Article Data: 1

Chemical Properties

• Appearance: White to Pale Yellow/Powder
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.19±0.20(Predicted)
• CAS DataBase Reference: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(199593-08-3)
• EPA Substance Registry System: N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE(199593-08-3)

Safety Data

• Hazardous Substances Data: 199593-08-3(Hazardous Substances Data)

Usage

General Description

N4-acetyl-5'-(dimethoxytrityl)-2'-O-methylcytidine is a chemical compound that belongs to the category of nucleosides. It is a modified form of cytidine with an acetyl group attached to the N4 position and a dimethoxytrityl group attached to the 5' position. Additionally, a methyl group is attached to the 2'-O position of the ribose sugar. This chemical modification makes it suitable for use in the synthesis of nucleic acids and as a building block for various nucleotide analogs. Its unique structure and properties make it valuable in the field of molecular biology and pharmaceutical research.

Upstream product

• 199593-14-1 N-[2-Oxo-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pyrimidin-4-yl]-acetamide 
• 3768-18-1 N-acetylcytidine 
• 85335-73-5 N₄-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine 

Downstream Products

• 1355047-25-4 C₄₆H₅₈N₅O₁₀P 
• 199593-09-4 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Relevant articles and documents

Ultrafast cleavage and deprotection of oligonucleotides synthesis and use of C(Ac) derivatives

We have investigated the use of alkylamines as fast cleavage and deprotection reagents for the solid phase synthesis of oligonucleotides and found methylamine/ammonium hydroxide (or methylamine) as an efficient reagent. The transamination side product formed with the commonly used dC(b2) has been eliminated by the use of dC(Ac) phosphoramidite. This system has successfully been used in the synthesis of oligonucleotides and oligonucleoside phosphorothioates. DMT dC(Ac) hydrogen phosphonate and DMT ribo C(Ac)-2'-OMe phosphoramidite also have been prepared and used in the synthesis of oligonucleotides.