1999-64-0

Basic information

• Product Name: 6-Ethyl-2-naphthol
• Synonyms: 2-Naphthalenol,6-ethyl-(9CI);6-ethylnaphthalen-2-ol;2-Ethyl-6-naphthol
• CAS NO: 1999-64-0
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.23
• Product Categories: NAPHTALENE
• Mol File: 1999-64-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 98℃
• Boiling Point: 322.3 °C at 760 mmHg
• Flash Point: 155.4 °C
• Appearance: /
• Density: 1.112 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.75±0.40(Predicted)
• CAS DataBase Reference: 6-Ethyl-2-naphthol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Ethyl-2-naphthol(1999-64-0)
• EPA Substance Registry System: 6-Ethyl-2-naphthol(1999-64-0)

Safety Data

• Hazardous Substances Data: 1999-64-0(Hazardous Substances Data)

Usage

General Description

6-Ethyl-2-naphthol, also known as 6-ethyl-2-hydroxynaphthalene, is a chemical compound with the molecular formula C12H12O. It is a white to off-white crystalline solid and is soluble in alcohol and ether but insoluble in water. 6-Ethyl-2-naphthol is primarily used as an intermediate in the synthesis of various pharmaceuticals, and it also finds application in the production of dyes, pigments, and fragrances. Additionally, it is used as a biochemical research reagent and as a flavor and fragrance agent. The compound is known to have low acute toxicity, but prolonged exposure may cause irritation to the skin, eyes, and respiratory tract. Overall, 6-Ethyl-2-naphthol is a versatile chemical with various industrial and research applications.

Upstream product

• 21388-17-0 2-methoxy-6-ethylnaphthalene 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 2386-64-3 ethylmagnesium chloride 
• 925-90-6 ethylmagnesium bromide 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 93-04-9 2-Methoxynaphthalene 

Downstream Products

• 63021-34-1 3-ethyl-dibenz[a,h]acridine 
• 612-94-2 2-phenylnaphthalene 
• 1597710-08-1 8-ethyl-2-(4-methylbenzoyl)-3H-benzo[f ]chromen-3-one 
• 1597709-89-1 4-[(6-ethyl-2-hydroxynaphthalen-1-yl)methyl]-5-(4-methylphenyl)-2,3-dihydro-1H-pyrazol-3-one 

Relevant articles and documents

Efficient demethylation of aromatic methyl ethers with HCl in water

A green, efficient and cheap demethylation reaction of aromatic methyl ethers with mineral acid (HCl or H2SO4) as a catalyst in high temperature pressurized water provided the corresponding aromatic alcohols (phenols, catechols, pyrogallols) in high yield. 4-Propylguaiacol was chosen as a model, given the various applications of the 4-propylcatechol reaction product. This demethylation reaction could be easily scaled and biorenewable 4-propylguaiacol from wood and clove oil could also be applied as a feedstock. Greenness of the developed methodversusstate-of-the-art demethylation reactions was assessed by performing a quantitative and qualitative Green Metrics analysis. Versatility of the method was shown on a variety of aromatic methyl ethers containing (biorenewable) substrates, yielding up to 99% of the corresponding aromatic alcohols, in most cases just requiring simple extraction as work-up.

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C -Glycosylation of Substituted β-Naphthols with Trichloroacetimidate Glycosyl Donors

Several glycosyl donors have been systematically investigated for C-glycosylation of substituted β-naphthols to delineate the effect of the substituents. Whereas glycosylations of the parent 2-naphthol are smoothly achievable, those of differently substituted 2-naphthols are cumbersome. Efficiency of the glycosylation depends on the nature of both the glycosyl donors and the substituents of the arene ring. Among various glycosyl donors, trichloroacetimidate glycosyl donors are found to be superior for glycosylation with substituted 2-naphthols.