199930-20-6

Basic information

• Product Name: 3-chloro-4-hydroxyphenylacetic acid 2,4,5-trichlorophenyl ester
• CAS NO: 199930-20-6
• Molecular Weight: 366.028
• Mol File: 199930-20-6.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-hydroxyphenylacetic acid 2,4,5-trichlorophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-hydroxyphenylacetic acid 2,4,5-trichlorophenyl ester(199930-20-6)
• EPA Substance Registry System: 3-chloro-4-hydroxyphenylacetic acid 2,4,5-trichlorophenyl ester(199930-20-6)

Safety Data

• Hazardous Substances Data: 199930-20-6(Hazardous Substances Data)

Upstream product

• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 95-95-4 2,4,5-trichlorophenol 

Relevant articles and documents

General process for the preparation of cyclic oligonucleotides

The preparation process starts with a protected nucleotide which is anchored through its phosphate group with an anchoring group that links the phosphate group to a polymeric support, its 5'-hydroxyl group is protected for chain elongation and its 3'-terminal phosphate group is protected with a chain phosphate protecting group. Elongation is carried out under conditions in which the protecting groups of adenine, cytosine and guanine remain unaltered and thymine and uracil groups are not protected. Chain phosphate protecting groups are removed from the obtained cyclic anchored intermediate. Then the product is cleaved from the polymeric support and the protecting groups of the nucleobases are removed. The process has the advantages of general utility for any bases and any size of cycle and of providing high yields with minor by-products. The cyclic oligonucleotides obtained have potential use as antisense products and probes, as well as in therapeutics and in diagnosis.