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19996-87-3

19996-87-3

Identification

Synonyms:Urea,1-phenyl-3-(3-pyrrolidinyl)- (8CI)

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:1-PHENYL-3-(3-PYRROLIDINYL)UREA 95.00%
  • Packaging:5MG
  • Price:$ 502.83
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:1-phenyl-3-(3-pyrrolidinyl)urea 97.00%
  • Packaging:25G
  • Price:$ 13300
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:1-phenyl-3-(3-pyrrolidinyl)urea 97.00%
  • Packaging:5G
  • Price:$ 5360
  • Delivery:In stock
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  • Manufacture/Brand:AccelPharmtech
  • Product Description:1-phenyl-3-(3-pyrrolidinyl)urea 97.00%
  • Packaging:1G
  • Price:$ 3120
  • Delivery:In stock
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Relevant articles and documentsAll total 1 Articles be found

Synthesis and Structure–Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

Modranka, Jakub,Li, Jiahong,Parchina, Anastasia,Vanmeert, Michiel,Dumbre, Shrinivas,Salman, Mayla,Myllykallio, Hannu,Becker, Hubert F.,Vanhoutte, Roeland,Margamuljana, Lia,Nguyen, Hoai,Abu El-Asrar, Rania,Rozenski, Jef,Herdewijn, Piet,De Jonghe, Steven,Lescrinier, Eveline

, p. 645 - 662 (2019/02/25)

Since the discovery of a flavin-dependent thymidylate synthase (ThyX or FDTS) that is absent in humans but crucial for DNA biosynthesis in a diverse group of pathogens, the enzyme has been pursued for the development of new antibacterial agents against Mycobacterium tuberculosis, the causative agent of the widespread infectious disease tuberculosis (TB). In response to a growing need for more effective anti-TB drugs, we have built upon our previous screening efforts and report herein an optimization campaign of a novel series of inhibitors with a unique inhibition profile. The inhibitors display competitive inhibition toward the methylene tetrahydrofolate cofactor of ThyX, enabling us to generate a model of the compounds bound to their target, thus offering insight into their structure–activity relationships.

Process route upstream and downstream products

Process route

C<sub>16</sub>H<sub>23</sub>N<sub>3</sub>O<sub>3</sub>

C16H23N3O3

1-phenyl-3-pyrrolidin-3-yl-urea
19996-87-3

1-phenyl-3-pyrrolidin-3-yl-urea

Conditions
Conditions Yield
With trifluoroacetic acid; In dichloromethane; at 0 ℃;
phenyl isocyanate
103-71-9

phenyl isocyanate

1-phenyl-3-pyrrolidin-3-yl-urea
19996-87-3

1-phenyl-3-pyrrolidin-3-yl-urea

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 20 °C
2: trifluoroacetic acid / dichloromethane / 0 °C
With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
1-phenyl-3-pyrrolidin-3-yl-urea
19996-87-3

1-phenyl-3-pyrrolidin-3-yl-urea

Conditions
Conditions Yield
1-Benzyl-3-(3-phenyl-ureido)-pyrrolidin, H2 (Pd/C);
3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoic acid
23866-15-1

3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoic acid

1-phenyl-3-pyrrolidin-3-yl-urea
19996-87-3

1-phenyl-3-pyrrolidin-3-yl-urea

1-(1-(3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoyl)pyrrolidin-3-yl)-3-phenylurea

1-(1-(3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propanoyl)pyrrolidin-3-yl)-3-phenylurea

Conditions
Conditions Yield
With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃;

19996-87-3 Upstream products

Global suppliers and manufacturers

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  • Bluecrystal chem-union
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  • Chemical Co.Ltd
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