200000-54-0

Basic information

• Product Name: N-BENZYL-4-FLUOROPHENYLGLYCINE
• Synonyms: (Benzylamino)(4-fluorophenyl)acetic acid;2-(benzyl(4-fluorophenyl)aMino)acetic acid;2-(Benzylamino)-2-(4-fluorophenyl)acetic acid
• CAS NO: 200000-54-0
• Molecular Formula: C₁₅H₁₄FNO₂
• Molecular Weight: 259.2786
• Mol File: 200000-54-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.247±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.76±0.10(Predicted)
• CAS DataBase Reference: N-BENZYL-4-FLUOROPHENYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-4-FLUOROPHENYLGLYCINE(200000-54-0)
• EPA Substance Registry System: N-BENZYL-4-FLUOROPHENYLGLYCINE(200000-54-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 200000-54-0(Hazardous Substances Data)

Usage

General Description

N-BENZYL-4-FLUOROPHENYLGLYCINE, also known as N-(4-Fluorophenyl)glycine benzyl ester, is a chemical compound that belongs to the class of glycine derivatives. It is commonly used as an intermediate for the synthesis of pharmaceuticals and agrochemicals. N-BENZYL-4-FLUOROPHENYLGLYCINE is a white to off-white solid with a molecular formula of C15H14FNO2 and a molecular weight of 261.28 g/mol. N-BENZYL-4-FLUOROPHENYLGLYCINE is known for its potential pharmacological properties and is used in the development of various drugs. It is important to handle this compound with care and adhere to proper safety measures when working with it in laboratory settings.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 100-46-9 benzylamine 
• 124-38-9 carbon dioxide 
• 1018683-57-2 C₁₄H₁₂FNO 
• 220130-49-4 [(diphenylmethyl)amino](4-fluorophenyl)acetonitrile 
• 271583-38-1 2-(N-benzyl)amino-2-(4-fluorophenyl)acetamide 

Downstream Products

• 159706-87-3 4-benzyl-3-(4-fluorophenyl)morpholin-2-one 
• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 
• 187876-68-2 3-(S)-(4-Fluorophenyl)-4-benzyl-2-morpholinone 

Relevant articles and documents

Synthesis of α-amino acids through samarium(II) iodide promoted reductive coupling of nitrones with CO2

Several N-benzylnitrones reacted with carbon dioxide in the presence of samarium(II) iodide leading to α-amino acids as the products of reductive C-C coupling. The best selectivities were observed at a carbon dioxide pressure of 50 bar at ambient temperature. The influences of different functional groups in the nitrone backbone and of the coordinating additives to samarium(II) iodide on the product distribution were investigated. The racemic α-amino acids were obtained in up to 70% yield based on HPLC data. A novel approach to the synthesis ofα-amino acids is disclosed, involvingC-carboxylation of nitrones by gaseous CO2 under reductive coupling reaction conditions (SmI2, 0.1 M in THF) at ambient temperature and 50 bar of CO 2 pressure. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Polymorphic form of a tachykinin receptor antagonist

This invention is concerned with a novel polymorphic form of the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)-ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma, and emesis. The instant polymorphic form has advantages over the other known forms of 2-(R)-(1-(R)-(3,5-bis(trifluoro-methyl)-phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.

MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS

Substituted heterocycles of the general structural formula: STR1 are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.