20034-51-9

Basic information

• Product Name: 2-CYCLOPROPYLBENZALDEHYDE
• Synonyms: AKOS BAR-1544;2-CYCLOPROPYLBENZALDEHYDE
• CAS NO: 20034-51-9
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.19
• Mol File: 20034-51-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CYCLOPROPYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYCLOPROPYLBENZALDEHYDE(20034-51-9)
• EPA Substance Registry System: 2-CYCLOPROPYLBENZALDEHYDE(20034-51-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20034-51-9(Hazardous Substances Data)

Usage

General Description

2-Cyclopropylbenzaldehyde, also known as 2-cyclopropylbenzene-1-carbaldehyde, is an organic compound with the formula C10H10O. It is a colorless liquid with a strong, aromatic odor and is mainly used as a flavor and fragrance ingredient. It is commonly found in perfumes, cosmetics, and food products, adding a sweet, floral scent. This chemical compound is also used in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other organic compounds. Additionally, 2-cyclopropylbenzaldehyde is known for its potential as an intermediate in organic synthesis, particularly in the preparation of heterocyclic compounds.

Upstream product

• 50-00-0 formaldehyd 
• 873-49-4 cyclopropylbenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 411235-57-9 cyclopropylboronic acid 
• 26979-32-8 7-Cyclopropylcycloheptatrien 
• 106-96-7 propargyl bromide 

Downstream Products

• 64107-24-0 N-(o-cyclopropylbenzylidene)-N'-amidino-hydrazine 
• 1231220-93-1 6-chloro-8-(2-cyclopropylphenyl)-2-methyl-9-(tetrahydropyran-4-yl)-9H-purine 
• 1227461-23-5 [6-(2-cyclopropyl-benzyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl]-quinolin-3-yl-amine 
• 55865-90-2 5-Cyclopropyl-4-methyl-2-nitro-phenol 
• 55865-91-3 1-Cyclopropyl-2-methyl-4-nitro-benzene 
• 55949-10-5 2-Cyclopropyl-1-methyl-3-nitro-benzene 
• 55865-89-9 3-cyclopropyl-4-methylphenol 
• 27546-46-9 2-methyl-1-cyclopropylbenzene 
• 3158-74-5 2-cyclopropylbenzoic acid 

Relevant articles and documents

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Suzuki coupling of cyclopropylboronic acid with aryl halides catalyzed by a palladium-tetraphosphine complex

The tetraphosphine all-cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)- cyclopentane (Tedicyp) in combination with [Pd(C3H 5)Cl]2 affords a very efficient catalyst for the coupling of cyclopropylboronic acid with aryl bromides and aryl chlorides. Higher reactions rates were observed with aryl bromides than with aryl chlorides; however, even in the presence of 1-0.4% of catalyst, a few aryl chlorides gave the coupling products in good yields. A wide variety of substituents such as alkyl, methoxy, trifluoromethyl, acetyl, benzoyl, formyl, carboxylate, nitro, and nitrile on the aryl halides are tolerated. The coupling reaction of sterically very congested aryl bromides such as bromomesitylene or 2,4,6-triisopropylbromobenzene also proceeds in good yields. Copyright Taylor & Francis LLC.