20062-62-8Relevant articles and documents
Investigation of the mercury(II) coordination chemistry of tris[(1-methylimidazol-2-yl)methyl]amine by X-ray crystallography and NMR
Bebout, Deborah C.,Garland, Melissa M.,Murphy, Geoffrey S.,Bowers, Edith V.,Abelt, Christopher J.,Butcher, Raymond J.
, p. 2578 - 2584 (2003)
The coordination chemistry of Hg(II) with tris[(1-methylimidazol-2-yl)methyl]amine (TMIMA) was investigated. The structures of [Hg(TMIMA)2](ClO4)2 (1), [Hg(TMIMA)(NCCH3)](ClO4)2 (2) and [Hg(TMIMA)Cl]2(HgCl4) (3) were characterized by X-ray crystallography. Complex 1 has six strong Hg-Nimidazoyt bonds ranging from 2.257(5) to 2.631(6) A. Ligand geometry suggests the Hg-N(NR3) distances of 2.959(6) A in 1 reflects weak bonding interactions. This complex has a 199Hg chemical shift of -1496 ppm, significantly upfield from nitrogen coordination complexes with lower coordination numbers. The five-coordinate complex 2 has Hg-N(NR3), Hg-Nimidazoyl and Hg-Nacetonitrile bond lengths of 2.642(8), 2.198(5) and 2.264(11) A, respectively. Complex 3 is also five coordinate, with Hg-N(NR3), Hg-Cl and average Hg-N imidazoyl distances in the cations of 2.758(7), 2.424(2) and 2.29(4) A, respectively. Conditions for slow exchange on the J(HgH) coupling time-scale were found for both 1: 1 metal-to-ligand complexes in acetonitrile-d3. Observed heteronuclear coupling constants were similar to those associated with Hg(II) substituted proteins with histidine-metal bonds. Solution and solid-state comparisons to the Hg(II) coordination chemistry of tetradenate pyridyl ligands are made. Relevance to development of 199Hg NMR as a metallobioprobe is discussed. The Royal Society of Chemistry 2003.
NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
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Page/Page column 20; 21, (2018/05/24)
The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.
Mechanochemical and conformational study of N-heterocyclic carbonyl-oxime transformations
Primoi, Ines,Hrenar, Tomica,Baumann, Kreimir,Krito, Lucija,Krii, Ivana,Tomi, Srdlanka
, p. 153 - 160 (2015/02/19)
New mechanochemical pathways for the transformation of six N-heterocyclic carbonyl compounds into oximes using hydroxylamine hydrochloride were explored. Reactions were performed first without any base since the heterocyclic moieties (imidazole, benzimidazole, pyridine and quinuclidine) have an intrinsic basic nitrogen atom. This green, solvent free method was suitable for all compounds (up to quantitative yields) except for N-benzyl substituted imidazole and benzimidazole-2-carbaldehyde. For the slower reacting aldehydes, reactions with liquid assisted grinding and addition of sodium hydroxide were performed as well. Conformational analysis and quantum-chemical calculations revealed steric and electronic reasons for the lower reactivity of N-benzyl substituted derivatives.
The effect of neutral oximes on the reactivation of human acetylcholinesterase inhibited with paraoxon
Ribeiro, Tatiana S.,Prates, Arthur,Alves, Se?rgio R.,Oliveira-Silva, Jefferson J.,Riehl, Carlos A. S.,Figueroa-Villar, J. Daniel
experimental part, p. 1216 - 1225 (2012/10/18)
Important defense agents against chemical warfare weapons, which are reactivators of human acetylcholinesterase (huAChE) inhibited by neurotoxic organophosphorus compounds (OP), need a reasonable permeation of the hematoencephalic barrier (HB). In this wo
