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CAS

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20085-85-2

Epicurzerenone is a synthetic 17β-hydroxy steroid derivative, characterized by its potent inhibitory effect on the enzyme 11β-hydroxysteroid dehydrogenase type 1. Epicurzerenone has demonstrated the ability to significantly reduce intracellular cortisol synthesis, positioning it as a promising agent for the treatment of glucocorticoid-related diseases.
Used in Pharmaceutical Industry:
Epicurzerenone is used as a therapeutic agent for managing glucocorticoid-related diseases such as diabetes, obesity, and metabolic syndrome. Its mechanism of action involves the specific targeting of the cortisol-producing enzyme, which is crucial in the regulation of these metabolic disorders.
Used in Diabetes Treatment:
Epicurzerenone is used as an antidiabetic drug to improve insulin sensitivity. By reducing cortisol levels, it can potentially enhance the body's response to insulin, thus aiding in the management of blood sugar levels.
Used in Obesity Management:
In the context of obesity, Epicurzerenone is used as a weight management aid. Its ability to influence cortisol synthesis may help in addressing the hormonal imbalances associated with obesity.
Used in Metabolic Syndrome Therapy:
Epicurzerenone is utilized as a component in the treatment of metabolic syndrome, where it can help mitigate the symptoms by reducing inflammation and improving overall metabolic health.
Used in Drug Development:
Epicurzerenone is used as a lead compound in pharmaceutical research and development. Its unique properties make it a valuable candidate for the creation of new drugs aimed at managing a variety of metabolic disorders.

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  • 20085-85-2 Structure

  • Basic information

    1. Product Name: Epicurzerenone
    2. Synonyms: Epicurzerenone;rel-(5R,6S)-6-Ethenyl-6,7-dihydro-3,6-dimethyl-5-(1-methylethenyl)-4(5H)-benzofuranone;5-epi-Curzerenone
    3. CAS NO:20085-85-2
    4. Molecular Formula: C15H18O2
    5. Molecular Weight: 230.30222
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 20085-85-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Epicurzerenone(CAS DataBase Reference)
    10. NIST Chemistry Reference: Epicurzerenone(20085-85-2)
    11. EPA Substance Registry System: Epicurzerenone(20085-85-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 20085-85-2(Hazardous Substances Data)

20085-85-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 20085-85-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,0,8 and 5 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 20085-85:
(7*2)+(6*0)+(5*0)+(4*8)+(3*5)+(2*8)+(1*5)=82
82 % 10 = 2
So 20085-85-2 is a valid CAS Registry Number.

20085-85-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Epicurzerenone

1.2 Other means of identification

Product number -
Other names (5R,6S)-5-Isopropenyl-3,6-dimethyl-6-vinyl-6,7-dihydro-5H-benzofuran-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:20085-85-2 SDS

20085-85-2Downstream Products

20085-85-2Relevant articles and documents

Total Synthesis of Curzerenone, Epicurzerenone, and Pyrocurzerenone

Miyashita, Masaaki,Kumazawa, Toshiaki,Yoshikoshi, Akira

, p. 3728 - 3732 (2007/10/02)

Curzerenone (1) and epicurzerenone (2), representative furanoelemanoids, and pyrocurzerenone (3) were synthesized via the 3-methylfuran annulation reaction using 1-nitro-1-(phenylthio)propene (4) as the crucial step.The cyclic 1,3-dione 6, derived from γ-

TOTAL SYNTHESIS OF CURZERENONE AND EPICURZERENONE

Miyashita, Masaaki,Kumazawa, Toshiaki,Yoshikoshi, Akira

, p. 593 - 596 (2007/10/02)

Curzerenone and epicurzerenone were synthesized by means of a combination of γ-ketoester synthesis and 3-methylfuran annulation both of which utilize nitroolefins as synthons.Starting material, methyl 2-methyl-4-oxo-2-vinylpentanoate, was prepared by the Lewis acid-promoted reaction of 1-methoxy-2-methyl-1--1,3-butadiene and 2-nitropropene, while key intermediate 3,6-dimethyl-6-vinyl-6,7-dihydrobenzofuran-4(5H)-one was assembled by KF-catalyzed reaction of 5-methyl-5-vinyl-cyclohexane-1,3-dione and 1-nitro-1-phenylthiopropene.

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