Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2018-19-1

6-AZAURIDINE-5'-MONOPHOSPHATE, also known as 6-Azauridine 5'-monophosphate or 6-Azauridine 5'-phosphate, is a chemical compound derived from the nucleoside 6-azauridine. It is a modified nucleotide, where the nitrogen atom at the 6th position of the pyrimidine ring is replaced by a carbon atom, resulting in a unique structure. 6-AZAURIDINE-5'-MONOPHOSPHATE is of interest in the field of biochemistry and molecular biology, as it can be used as a building block for the synthesis of modified nucleic acids. These modified nucleic acids have potential applications in the development of new therapeutics, such as antiviral and anticancer drugs, due to their ability to interact with enzymes and other cellular targets in a different manner compared to natural nucleotides. The 5'-monophosphate group attached to the 6-azauridine base allows for its incorporation into nucleic acid chains, making it a valuable tool in the study and development of novel biologically active molecules.

2018-19-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

  • [(2R,3S,4R,5R)-5-(3,5-dioxo-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate

    Cas No: 2018-19-1

  • USD $ 1.9-2.9 / Gram

  • 100 Gram

  • 1000 Metric Ton/Month

  • Chemlyte Solutions
  • Contact Supplier
  • 2018-19-1 Structure

  • Basic information

    1. Product Name: 6-AZAURIDINE-5'-MONOPHOSPHATE
    2. Synonyms: 6-AZAURIDINE-5'-MONOPHOSPHATE;6-Aza UMP;6-Azauridine 5'-phosphoric acid;[(2R,3S,4R,5R)-5-(3,5-diketo-1,2,4-triazin-2-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-5-(3,5-dioxo-1,2,4-triazin-2-yl)-3,4-dihydroxy-oxolan-2-yl]methyl dihydrogen phosphate;[(2R,3S,4R,5R)-5-(3,5-dioxo-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
    3. CAS NO:2018-19-1
    4. Molecular Formula: C8H12N3O9P
    5. Molecular Weight: 325.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2018-19-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: °Cat760mmHg
    3. Flash Point: °C
    4. Appearance: /
    5. Density: 2.33g/cm3
    6. Refractive Index: 1.809
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-AZAURIDINE-5'-MONOPHOSPHATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-AZAURIDINE-5'-MONOPHOSPHATE(2018-19-1)
    11. EPA Substance Registry System: 6-AZAURIDINE-5'-MONOPHOSPHATE(2018-19-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2018-19-1(Hazardous Substances Data)

2018-19-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2018-19-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,1 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2018-19:
(6*2)+(5*0)+(4*1)+(3*8)+(2*1)+(1*9)=51
51 % 10 = 1
So 2018-19-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N3O9P/c12-4-1-9-11(8(15)10-4)7-6(14)5(13)3(20-7)2-19-21(16,17)18/h1,3,5-7,13-14H,2H2,(H,10,12,15)(H2,16,17,18)/t3-,5-,6-,7-/m1/s1

2018-19-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-aza-uridine 5'-monophosphate

1.2 Other means of identification

Product number -
Other names 6-AZAURIDINE-5'-MONOPHOSPHATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2018-19-1 SDS

2018-19-1Downstream Products

2018-19-1Relevant articles and documents

Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics

Poduch, Ewa,Bello, Angelica M.,Tang, Sishi,Fujihashi, Masahiro,Pai, Emil F.,Kotra, Lakshmi P.

, p. 4937 - 4945 (2007/10/03)

Inhibitors of orotidine monophosphate decarboxylase (ODCase) have applications in RNA viral, parasitic, and other infectious diseases. ODCase catalyzes the decarboxylation of orotidine monophosphate (OMP), producing uridine monophosphate (UMP). Novel inhibitors 6-amino-UMP and 6-cyano-UMP were designed on the basis of the substructure volumes in the substrate OMP and in an inhibitor of ODCase, barbituric acid monophosphate, BMP. A new enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. The reaction rates were measured by monitoring the heat generated during the decarboxylation reaction of orotidine monophosphate. Kinetic parameters (kcat = 21 s-1 and KM = 5 μM) and the molar enthalpy (ΔHapp = 5 kcal/mol) were determined for the decarboxylation of the substrate by ODCase. Competitive inhibition of the enzyme was observed and the inhibition constants (Ki) were determined to be 12.4 μm and 29 μM for 6-aza-UMP and 6-cyano-UMP, respectively. 6-Amino-UMP was found to be among the potent inhibitors of ODCase, having an inhibition constant of 840 nM. We reveal here the first inhibitors of ODCase designed by the principles of bioisosterism and a novel method of using isothermal calorimetry for enzyme inhibition studies.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2018-19-1